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G-quadruplex

A unique 7p/12q chromosomal abnormality associated with recurrent abortion and hypofibrinogenemia

114 views | Jun 10 2023

Recurrent first-trimester abortions in a 25-year-old woman with hypofibrinogenemia and a unique chromosomal abnormality (t(7;12)) suggest a potential relationship between the two conditions, while successful gestation following fibrinogen infusion indicates the critical role of fibrinogen concentration in securing implantation [Read the Full Post]

Stabilization of the Quadruplex-Forming G-Rich Sequences in the Rhinovirus Genome Inhibits Uncoating-Role of Na+ and K

90 views | Jun 10 2023

This research investigated the potential of G-quadruplex structures in inhibiting the replication cycle of rhinoviruses, with GQ-stabilizing compounds interfering with viral uncoating and promoting the formation and/or stabilization of GQs, impairing RNA unraveling and release from the virion. [Read the Full Post]