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Inhibitors of the Ubiquitin-Mediated Signaling Pathway Exhibit Broad-Spectrum Antiviral Activities against New World Alphaviruses

91 views | May 24 2023

The study investigated the use of small molecule inhibitors that interfere with UPS-associated signaling pathways as potential therapeutic candidates for treating mosquito-transmitted alphaviruses such as VEEV and EEEV, and found that three of them exhibited broad-spectrum antiviral activity against both viruses. [Read the Full Post]