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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

CD markers

Tumor Microenvironment Responsive CD8+ T Cells and Myeloid-Derived Suppressor Cells to Trigger CD73 Inhibitor AB680-Based Synergistic Therapy for Pancreatic Cancer

150 views | Jan 31 2024

AB680, a potent CD73 inhibitor, demonstrates significant efficacy in augmenting CD8+ T cell infiltration, prolonging survival, and when combined with PD-1 blockade while attenuating gemcitabine's effects, offering a promising immunotherapeutic strategy in pancreatic ductal adenocarcinoma. [Read the Full Post]

Active Components of Leontopodium alpinum Callus Culture Extract for Blue Light Damage in Human Foreskin Fibroblasts

595 views | Dec 31 2023

Research on Leontopodium alpinum callus culture extract's components, particularly leontopodic acid A, reveals promising potential in protecting skin cells from blue light damage, offering avenues for future skincare and pharmaceutical developments. [Read the Full Post]

C5a-C5aR1 induces endoplasmic reticulum stress to accelerate vascular calcification via PERK-eIF2α-ATF4-CREB3L1 pathway

236 views | Dec 30 2023

High levels of C5a accelerate vascular smooth muscle cell calcification via C5aR1, activating the PERK-eIF2α-ATF4-CREB3L1 pathway, highlighting C5 or C5aR1 as potential therapeutic targets for vascular calcification. [Read the Full Post]

Exercise attenuates neuronal degeneration in Parkinson's disease rat model by regulating the level of adenosine 2A receptor

584 views | Dec 23 2023

Exercise appears to mitigate Parkinson's disease symptoms in rats by reducing neurodegeneration through a-synuclein aggregation reduction and adenosine 2A receptor modulation, although the co-administration of an adenosine A2A receptor agonist reverses these beneficial effects. [Read the Full Post]

Effects of Apocynin, a NADPH Oxidase Inhibitor, in the Protection of the Heart from Ischemia/Reperfusion Injury

141 views | Sep 12 2023

The study found that infusion of apocynin before ischemia or at reperfusion protected the heart by improving cardiac hemodynamics, reducing infarct size, decreasing pro-inflammatory cytokine levels, increasing anti-inflammatory cytokine and antioxidant levels, and involving CD38, nitric oxide, and acidic stores. [Read the Full Post]

PPARδ inhibition blocks the induction and function of tumor-induced IL-10+ regulatory B cells and enhances cancer immunotherapy

156 views | Sep 12 2023

This study demonstrates that PPARδ is crucial for the development and function of IL-10+ Bregs, and targeting PPARδ shows promise in improving antitumor immunotherapy outcomes. [Read the Full Post]

Identification of potential drug targets for vascular dementia and carotid plaques by analyzing underlying molecular signatures shared by them

192 views | Dec 13 2022

Jun Shu et al.found that inflammatory and immune-related processes be a crucial common pathophysiological mechanism shared by VaD and carotid plaques. [Read the Full Post]

The complement system in antineutrophil cytoplasmic antibody-associated vasculitis: pathogenic player and therapeutic target

208 views | Dec 13 2022

Martina Mazzariol et al. found that avacopan, a C5aR inhibitor, showed beneficial effects in AAV and representd a promising therapy to achieve sustained remission and to spare glucocorticoids. [Read the Full Post]