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Archives
VDAC
Inhibition of mitochondrial VDAC1 oligomerization alleviates apoptosis and necroptosis of retinal neurons following OGD/R injury
94 views | Oct 26 2023
The study found that inhibiting the oligomerization of Voltage-dependent anion channel 1 (VDAC1) rescues mitochondrial dysfunction and reduces apoptosis/necroptosis in retinal cells, offering a potential therapeutic strategy for ocular diseases caused by ischemia-reperfusion injury. [Read the Full Post]
Microglial VDAC1 signaling modulates sleep deprivation-induced transition to chronic postsurgical pain
147 views | Apr 18 2023
This study demonstrates that sleep deprivation before and after surgery increases the risk of chronic pain by activating spinal microglia, and that VDAC1 signaling regulates microglial activation-related ATP release, inflammation, and pain chronicity in mice. [Read the Full Post]
Congenital sideroblastic anemia model due to ALAS2 mutation is susceptible to ferroptosis
212 views | Jun 05 2022
Koya Ono et al. found that defective heme biosynthesis in XLSA clones could confer enhanced BACH1 expression, leading to increased susceptibility to ferroptosis. [Read the Full Post]
Dihydroquercetin Attenuates Silica-Induced Pulmonary Fibrosis by Inhibiting Ferroptosis Signaling Pathway
333 views | Jun 02 2022
Leyong Yuan et al. found that inhibition of ferritinophagy-mediated HBE cells ferroptosis was responsible for DHQ to ameliorate SiO2-induced lung fibrosis, which provided a preliminary theoretical basis for the clinical application of DHQ in the treatment of silicosis. [Read the Full Post]
Mechanism of Ferroptosis and Its Role in Type 2 Diabetes Mellitus
664 views | Jul 15 2021
Wenxin Sha et al. summarized the mechanism of ferroptosis and especially its association with type 2 diabetes mellitus (T2DM). [Read the Full Post]
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