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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

MMP

Astaxanthin: A Marine Drug That Ameliorates Cerebrovascular-Damage-Associated Alzheimer's Disease in a Zebrafish Model via the Inhibition of Matrix Metalloprotease-13

96 views | Jan 15 2024

This study suggests that astaxanthin may offer promise in mitigating Alzheimer's disease-related cognitive and biochemical changes in zebrafish by inhibiting MMP-13 activity, potentially indicating a multi-targeted therapeutic approach for AD management. [Read the Full Post]

Regional regulatory harmonisation initiatives: Their potential contribution to the newly established African medicines agency

510 views | Nov 30 2023

The study highlights the foundational role of regional medicines regulatory harmonization programs, such as the African Medicines Regulatory Harmonisation (AMRH) and East African Community Medicines Regulatory Harmonisation (EAC-MRH) initiatives, in supporting the operationalization of the African Medicine Agency (AMA), emphasizing the importance of strong national regulatory authorities and increased ratification of the AMA Treaty for ensuring access to essential medical products and technologies for the African people. [Read the Full Post]

Nobiletin Mitigates D-Galactose-Induced Memory Impairment via Improving Hippocampal Neurogenesis in Mice

155 views | Nov 05 2023

The study found that administration of nobiletin (NOB) attenuated memory impairment, restored hippocampal neurogenesis, reduced neuroinflammation, and improved brain function in D-galactose-induced aging mice, suggesting NOB as a potential neurogenesis enhancer for mitigating brain aging. [Read the Full Post]

Cordycepin inhibits myogenesis via activating the ERK1/2 MAPK signalling pathway in C2C12 cells

90 views | Nov 05 2023

Cordycepin inhibits myoblast differentiation by downregulating MyoD and MyoG, while preserving undifferentiated reserve cell pools through upregulation of Myf5 and p130, enhancing energy reserves, and activating ERK1/2 MAPK signaling, suggesting its potential for preventing and treating degenerative muscle diseases. [Read the Full Post]

Hepatocytic AP-1 and STAT3 contribute to chemotaxis in alphanaphthylisothiocyanate-induced cholestatic liver injury

262 views | Sep 13 2023

The study demonstrated that the AP-1 signaling pathway is more crucial than STAT3 in mediating the inflammatory cascade of ANIT-induced CLI, and hepatocytes, rather than Kupffer cells, release chemotactic factors involved in chemotaxis during CLI. [Read the Full Post]

S-1-propenyl-L-cysteine suppresses lipopolysaccharide-induced expression of matrix metalloproteinase-1 through inhibition of tumor necrosis factor-α converting enzyme-epidermal growth factor receptor axis in human gingival fibroblasts

133 views | Jun 09 2023

S-1-propenyl-L-cysteine, a sulfur bioactive compound found in aged garlic extract, suppresses the expression of matrix metalloproteinase-1 through inhibition of the tumor necrosis factor-α converting enzyme-epidermal growth factor receptor axis in gingival fibroblasts, suggesting it may be an effective therapeutic agent for periodontal disease. [Read the Full Post]

OONO-/MMP2/MMP9 pathway-mediated apoptosis of porcine granulosa cells is associated with DNA damage

181 views | Jun 09 2023

The passage describes a new mechanism for porcine follicular atresia involving peroxynitrite anion, which can increase the expression of matrix metalloproteinase 2 and 9, resulting in DNA damage, inhibition of DNA repair and apoptosis of granulosa cells. [Read the Full Post]

Targeting tumour-associated macrophages in hodgkin lymphoma using engineered extracellular matrix-mimicking cryogels

81 views | May 25 2023

The researchers used a biomimetic cryogel model to screen for invasion inhibitors and identified five drug hits, including ruxolitinib and PD-169316, which decreased tumor-associated macrophage invasion and modulated macrophage polarization in Hodgkin lymphoma. [Read the Full Post]

Metalloprotease domain latency protects ADAMTS13 against broad-spectrum inhibitors of metalloproteases while maintaining activity towards VWF

150 views | May 25 2023

The study found that the metalloprotease domain of ADAMTS13 protects it from inhibitors and exists in a latent state that is partially maintained by loops flanking the S1 and S1' specificity pockets. [Read the Full Post]

Peptidoglycan from Bacillus anthracis Inhibits Human Macrophage Efferocytosis in Part by Reducing Cell Surface Expression of MERTK and TIM-3

108 views | May 25 2023

The study found that Bacillus anthracis peptidoglycan inhibits the capacity of human monocyte-derived macrophages to efferocytose apoptotic cells by reducing cell surface expression of efferocytic receptors, dependent on human serum opsonins and involving proteases. [Read the Full Post]