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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Caspase

Experimental and Theoretical Estimations of Atrazine's Adsorption in Mangosteen-Peel-Derived Nanoporous Carbons

192 views | Nov 06 2023

This study investigated the removal of atrazine using nanoporous carbons derived from mangosteen-peel chars, focusing on the role of nitrogen groups and surface chemistry, and elucidating the importance of micropores and mesopores in the adsorption process. [Read the Full Post]

Genome-wide CRISPR screening reveals key genes and pathways associated with 20-hydroxyecdysone signal transduction in the silkworm (Bombyx mori)

388 views | Oct 26 2023

This study utilized a genome-wide CRISPR/Cas9-based library to identify key genes involved in the 20E signaling pathway in the silkworm, shedding light on the mechanisms underlying metamorphosis and hormone regulation. [Read the Full Post]

Preparation and Properties of Natural Polysaccharide-Based Drug Delivery Nanoparticles

310 views | Oct 05 2023

The paper presents the development of RGD-(NPGP/CS)3NPGP nanoparticles through layer-by-layer assembly, which demonstrate high encapsulation efficiency, pH-sensitive release, and effective targeting to integrin receptor-expressing tumor cells, making them promising as novel anticancer drug carriers. [Read the Full Post]

Pathway network of pyroptosis and its potential inhibitors in acute kidney injury

349 views | Sep 23 2023

This article reviews the role of pyroptosis in acute kidney injury (AKI), focusing on the assembly and activation of the NLRP3 inflammasome and its downstream inflammatory cytokines as potential therapeutic targets for novel AKI therapies. [Read the Full Post]

Downregulated XBP-1 Rescues Cerebral Ischemia/Reperfusion Injury-Induced Pyroptosis via the NLRP3/Caspase-1/GSDMD Axis

229 views | Aug 08 2023

Downregulation of XBP-1 inhibits pyroptosis through the NLRP3/Caspase-1/GSDMD pathway, providing neuronal protection in the context of cerebral ischemia/reperfusion injury. [Read the Full Post]

Cellular senescence in the response of HR+ breast cancer to radiotherapy and CDK4/6 inhibitors

403 views | Aug 06 2023

The study findings suggest that the inferiority of CDK4/6 inhibition followed by radiation therapy (P→RT) compared to radiation therapy followed by CDK4/6 inhibition (RT→P) in preclinical models of HR+ breast cancer may be partially attributed to the differential accumulation of senescent cells in the tumor microenvironment. [Read the Full Post]

Hexavalent chromium disrupts the skin barrier by targeting ROS-mediated mitochondrial pathway apoptosis in keratinocytes

212 views | Jul 17 2023

This study demonstrates that hexavalent chromium (Cr(VI)) exposure leads to skin deterioration, hemorrhaging, collagen fiber layer thinning, impaired membrane integrity, and apoptosis primarily targeting keratinocytes, highlighting the importance of apoptosis and ROS-mediated mitochondrial pathway in Cr(VI)-induced skin barrier injury. [Read the Full Post]

Chemical screen identifies shikonin as a broad DNA damage response inhibitor that enhances chemotherapy through inhibiting ATM and ATR

204 views | Jul 17 2023

Shikonin, a recently identified inhibitor of the DNA damage response (DDR), has been found to suppress DDR activation by targeting ATM and ATRIP, leading to enhanced anti-cancer effects of chemotherapy, making it a potential candidate for chemotherapy sensitization. [Read the Full Post]

Fangchinoline Exerts Anticancer Effects on Colorectal Cancer Cells by Evoking Cell Apoptosis via Endoplasmic Reticulum Stress

311 views | Jul 04 2023

Fangchinoline (FAN) induces apoptosis in human colorectal cancer cells by activating endoplasmic reticulum stress through the upregulation of ER stress-related proteins and the involvement of the CHOP pathway. [Read the Full Post]

Celastrol inhibits necroptosis by attenuating the RIPK1/RIPK3/MLKL pathway and confers protection against acute pancreatitis in mice

0 views | Jun 27 2023

Celastrol demonstrates potential as a therapeutic agent for inhibiting necroptosis and reducing the severity of necroptotic-related diseases such as pancreatitis [Read the Full Post]