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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

IκB/IKK

Pharmacological inhibition of TBK1/IKKε blunts immunopathology in a murine model of SARS-CoV-2 infection

120 views | Nov 28 2023

In this study, researchers discovered that the small molecule idronoxil inhibits TBK1/IKKε signaling, attenuating hyper-inflammation in SARS-CoV-2-challenged mice and establishing a critical role for TBK1/IKKε signaling in severe COVID-19 pathology. [Read the Full Post]

Reducing the Invasiveness of Low- and High-Grade Endometrial Cancers in Both Primary Human Cancer Biopsies and Cell Lines by the Inhibition of Aquaporin-1 Channels

133 views | Nov 21 2023

Inhibition of AQP1 ion channels using specific inhibitors AqB011 and PMFC demonstrates significant reduction in invasiveness of both low- and high-grade endometrial cancer cells, indicating a promising therapeutic strategy to impede tumor progression and enhance patient outcomes. [Read the Full Post]

Promotion of Knee Cartilage Degradation by IκB Kinase ε in the Pathogenesis of Osteoarthritis in Human and Murine Models

103 views | Sep 10 2023

The study demonstrates that IKKε regulates cartilage degradation in osteoarthritis through NF-κB signaling and suggests that IKKε inhibition, exemplified by BAY-985, may serve as an effective modulatory treatment for the disease. [Read the Full Post]

Efficient and Stable β-CsPbI3 Solar Cells through Solvent Engineering with Methylamine Acetate Ionic Liquid

201 views | Sep 09 2023

The utilization of MAAc solvent and the incorporation of strong C═O···Pb coordination enabled the controllable growth of β-CsPbI3 perovskite thin films with a compact morphology and facilitated the achievement of efficient and stable perovskite solar cells (PSCs) with an efficiency of 18.9% and improved stability even in humid environments. [Read the Full Post]

Establishment and characterization of Yellow River carp (Cyprinus carpio haematopterus) muscle cell line and its application to fish virology and immunology

229 views | Sep 09 2023

This study presents the establishment of a novel Yellow River carp muscle cell line (CCM) and explores its immune response strategies to lipopolysaccharide (LPS) and poly (I:C), providing a valuable tool for fish immunology research. [Read the Full Post]

A Point Mutation at C151 of Keap1 of Mice Abrogates NRF2 Signaling, Cytoprotection In Vitro and Hepatoprotection In Vivo by Bardoxolone Methyl (CDDO-Me)

380 views | Jul 16 2023

The mutation of the KEAP1 cysteine 151 sensor in mouse models abrogates the induction of NRF2 signaling and the subsequent cytoprotective actions of bardoxolone methyl (CDDO-Me), emphasizing its crucial role in mediating the drug's therapeutic effects. [Read the Full Post]

Exploring the common pathogenesis of Alzheimer's disease and type 2 diabetes mellitus via microarray data analysis

174 views | Jul 14 2023

This study identified common differentially expressed genes, highlighted the importance of immune, hormonal, and neurotransmitter pathways, and identified potential drug candidates and key hub genes associated with Alzheimer's Disease and Type 2 Diabetes Mellitus. [Read the Full Post]

Inhibitors of the Oncogenic PA2G4-MYCN Protein-Protein Interface

381 views | Jun 09 2023

The discovery of WS6 analogues that inhibit the PA2G4-MYCN interaction represents a promising breakthrough in neuroblastoma treatment and potentially other MYCN-driven cancers, with reduced toxicity towards normal cells. [Read the Full Post]

Regulation of programmed death ligand 1 expression by interferon-γ and tumour necrosis factor-α in canine tumour cell lines

184 views | Apr 12 2023

The study demonstrates that upregulation of PD-L1 expression in canine tumours is regulated by the JAK-STAT and NF-κB signaling pathways upon stimulation with IFN-γ and TNF-α, respectively. [Read the Full Post]

Activation of Most Toll-Like Receptors in Whole Human Blood Attenuates Platelet Deposition on Collagen under Flow

227 views | Apr 11 2023

The study found that TLR signaling plays a complex role in platelet function under flow conditions and that the effects of TLR activation on platelet deposition depend on the specific TLR and its ligand, and that IKK and NF-κB inhibitors may be effective in inhibiting platelet deposition under flow. [Read the Full Post]