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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Antiviral

Utilization, reimbursement, and price trends for Hepatitis C virus medications in the US Medicaid programs: 2001-2021

122 views | Feb 10 2024

The study delineates the shifting landscape of HCV treatment from conventional therapies to expensive yet effective DAA agents, emphasizing the critical role of treatment guidelines and policies in influencing market dynamics and accessibility despite persistent challenges in affordability. [Read the Full Post]

Lithium chloride treatments in free flying honey bee colonies: efficacy, brood survival, and within-colony distribution

154 views | Feb 08 2024

The study demonstrates the potential effectiveness of lithium chloride as an acaricide in honey bee colonies, showing high efficacy in eradicating Varroa destructor in both broodless and brood-containing colonies without long-term adverse effects, warranting further investigation for optimizing treatment duration to achieve consistently high efficacy. [Read the Full Post]

Purification of thioredoxin reductase from Spirulina platensis by affinity chromatography and investigation of kinetic properties

159 views | Feb 05 2024

"In this study, TrxR enzyme from Spirulina platensis was successfully purified, characterized, and found to exhibit optimal activity at pH 7.0 and 40°C, demonstrating sensitivity to various metal ions, with Se4+ enhancing activity while others displayed inhibitory effects." [Read the Full Post]

Covid-19 co-infection with Crimean Congo haemorrhagic fever (CCHF) in a CCHF endemic country: a case report

335 views | Jan 22 2024

In regions where both Crimean-Congo hemorrhagic fever and severe COVID-19 coexist, differentiating between the two diseases is vital due to their overlapping clinical presentations, emphasizing the importance of accurate diagnostic testing to guide appropriate treatment strategies. [Read the Full Post]

Mitochondrial complex I inhibition by homoharringtonine: A novel strategy for suppression of chronic myeloid leukemia

179 views | Jan 18 2024

The rigorous evaluation of HHT's anti-CML effects, particularly its disruption of oxidative phosphorylation via mitochondrial complex I inhibition, unveils a promising therapeutic strategy to overcome resistance associated with the BCR-ABL T315I mutation. [Read the Full Post]

Segmental Zoster Paresis Accompanied by Horner's Syndrome

556 views | Nov 11 2023

In this case, a 90-year-old immunocompromised woman developed right upper limb weakness and Horner's syndrome following oral therapy for zoster on the right T2 dermatome, with aggressive intravenous treatment leading to improvement in the former but persistence of the latter. [Read the Full Post]

Deglycosylation of SLAMF7 in breast cancers enhances phagocytosis

86 views | Oct 24 2023

This study demonstrates that targeting N-glycosylation of SLAMF7 through an antibody-drug conjugate can enhance antibody affinity and phagocytosis, potentially improving the response of immunotherapeutic agents in breast cancer treatment. [Read the Full Post]

Regulation, genomics, and clinical characteristics of cuproptosis regulators in pan-cancer

294 views | Jul 16 2023

This study comprehensively elucidated the expression, prognostic significance, biological functions, genomic characteristics, immune microenvironment interactions, and drug sensitivity of cuproptosis regulators in pan-cancer, providing valuable insights into their potential role in cancer biology. [Read the Full Post]

Celastrol inhibits necroptosis by attenuating the RIPK1/RIPK3/MLKL pathway and confers protection against acute pancreatitis in mice

0 views | Jun 27 2023

Celastrol demonstrates potential as a therapeutic agent for inhibiting necroptosis and reducing the severity of necroptotic-related diseases such as pancreatitis [Read the Full Post]

Stability-Indicating Method Development and Validation for Quantitative Estimation of Assay and Organic Impurities of anti-viral drug Baloxavir-Marboxil in Drug Substance and Pharmaceutical Dosage Form using HPLC and LC-MS Methods

168 views | May 06 2023

A liquid chromatographic method was developed and validated for estimating the assay and impurities of Baloxavir-Marboxil in drug substance and pharmaceutical formulations, demonstrating reliable and robust separation of known and unknown impurities and stability-indicating properties. [Read the Full Post]