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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

PKM

Updates and advances in pyruvate kinase deficiency

119 views | Oct 19 2023

Mutations in the PKLR gene lead to pyruvate kinase deficiency, causing chronic hemolytic anemia, and recent advancements in treatment options include the use of an oral allosteric PK activator called mitapivat and ongoing clinical trials for gene therapy. [Read the Full Post]

Dual roles of β-arrestin 1 in mediating cell metabolism and proliferation in gastric cancer

134 views | Oct 18 2023

The study demonstrates that β-Arrestin 1 (ARRB1) plays a crucial role in gastric cancer cell metabolism and proliferation, with its subcellular localization determining its dual functions and suggesting the therapeutic potential of targeting the ARRB1-PKM2 axis. [Read the Full Post]

Hybrid Analogues of Hydrazone and Phthalimide: Design, Synthesis, In vivo, In vitro, and In silico Evaluation as Analgesic Agents

217 views | Aug 15 2023

A new series of hybrid hydrazone and phthalimide compounds were synthesized and evaluated, showing significant analgesic activity, selective COX-2 inhibition, and favorable cytostatic properties with a high therapeutic index. [Read the Full Post]

Recombinant Treponema pallidum Protein Tp47 Promoted the Phagocytosis of Macrophages by Activating NLRP3 Inflammasome Induced by PKM2-Dependent Glycolysis

91 views | Aug 15 2023

Tp47-induced activation of glycolysis and the NLRP3 inflammasome in macrophages promotes phagocytosis, with the upregulation of the M2 isoform of pyruvate kinase (PKM2) playing a crucial role in glycolysis-dependent NLRP3 activation. [Read the Full Post]

pH-sensitive smart indicators based on cellulose and different natural pigments for tracing kimchi ripening stages

688 views | Jul 27 2023

The study found that cellulose-based pH-sensitive indicators loaded with natural pigments showed more pronounced color changes in response to lactic acid and pH variations, with alkalized indicators being particularly effective for monitoring the fermentation process of acidic foods such as kimchi. [Read the Full Post]

PKM2/PDK1 dual-targeted shikonin derivatives restore the sensitivity of EGFR-mutated NSCLC cells to gefitinib by remodeling glucose metabolism

123 views | Jun 03 2023

The authors proposed a "two-step approach" to target both PKM2 and PDK1 simultaneously, and designed a novel PKM2/PDK1 dual-target agent E5, which showed promising anti-tumor activity and restored the sensitivity of EGFR-TKIs resistant NSCLC cells to gefitinib. [Read the Full Post]

Jmjd4 Facilitates Pkm2 Degradation in Cardiomyocytes and Is Protective Against Dilated Cardiomyopathy

151 views | Jun 03 2023

The study found that Jmjd4 plays a critical role in maintaining metabolic homeostasis in adult cardiomyocytes by degrading Pkm2 and its deficiency may lead to DCM, which suggests that targeting Jmjd4 and Pkm2 may be a potential therapeutic strategy for DCM and other cardiac diseases with metabolic dysfunction. [Read the Full Post]