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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

NKCC

Dichloroacetic acid and rapamycin synergistically inhibit tumor progression

502 views | Aug 15 2023

Rapamycin treatment leads to the inactivation of the pyruvate dehydrogenase complex (PDHc) through mTOR signaling inhibition, reducing cancer cells' response to rapamycin, while reactivating PDHc with dichloroacetic acid (DCA) enhances their susceptibility to rapamycin treatment. [Read the Full Post]

Predictors of Poor Very Early Diuretic Response and Effectiveness of Early Tolvaptan in Symptomatic Acute Heart Failure

120 views | Feb 27 2023

Early administration of tolvaptan (TLV) in patients with acute decompensated heart failure (ADHF) who have a predicted poor diuretic response (DR) can improve DR and reduce the risk of worsening renal function, according to a multicenter retrospective study. [Read the Full Post]

A case of ascetic fluid Mycobacterium aubagnense infection in a patient with severe peritoneal effusion

251 views | Feb 27 2023

This is a case report of the first instance of Mycobacterium aubagnense being isolated from ascites in a patient with severe peritoneal effusion, highlighting the need for further research to determine the clinical significance of the infection and effective treatment strategies. [Read the Full Post]