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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Prostaglandin Receptor

Heteroplasmic pathogenic m.12315G>A variant in MT-TL2 presenting with MELAS syndrome and depletion of nitric oxide donors

188 views | Dec 25 2023

This report highlights a 5-year-old child's neurological regression and stroke-like episodes associated with the MT-TL2 m.12315G>A mitochondrial variant, emphasizing the significance of detailed biochemical analyses and tailored treatments to expand the understanding and management of this rare condition. [Read the Full Post]

Four-Component Strain-Release-Driven Synthesis of Functionalized Azetidines

158 views | May 30 2023

This passage describes a successful and rapid multicomponent [1,2]-Brook rearrangement/strain-release-driven anion relay sequence for the modular synthesis of substituted azetidines, which was demonstrated through the 4-step synthesis of the EP2 receptor antagonist PF-04418948. [Read the Full Post]

Papain Exerts an Anti-atherosclerosis Effect with Suppressed MPA-mediated Foam Cell Formation by Regulating the MAPK and PI3K/Akt-NF-κB Pathways

405 views | Apr 13 2023

The study found that papain inhibits MPA-induced foam cell formation by inactivating the MAPK and PI3K/Akt-NF-κB pathways, thereby exerting an anti-AS effect. [Read the Full Post]