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FOXM1

RNF112-mediated FOXM1 ubiquitination suppresses the proliferation and invasion of gastric cancer

443 views | Sep 27 2023

RNF112 suppresses gastric cancer progression by directly ubiquitinating FOXM1, making the RNF112/FOXM1 axis a potential prognostic biomarker and therapeutic target in gastric cancer. [Read the Full Post]

FOXM1 augments sorafenib resistance and promotes progression of hepatocellular carcinoma by epigenetically activating KIF23 expression

95 views | Sep 19 2023

The study revealed that upregulation of FOXM1 in hepatocellular carcinoma (HCC) cells contributes to sorafenib resistance and HCC progression by increasing the expression of KIF23, and targeting FOXM1 could be an effective treatment strategy for HCC. [Read the Full Post]