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Autophagy
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MAPK
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Cell Cycle
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TGF-beta/Smad
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DNA Damage/DNA Repair
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Stem Cells & Wnt
- GSK-3
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- Wnt/beta-catenin
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- PKA
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Hippo
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Ubiquitin
- Proteasome
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Neuronal Signaling
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NF-κB
- HDAC
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GPCR & G Protein
- Ras
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- MT Receptor
- PAFR
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- LTR
- Adenosine Receptor
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- cAMP
- CXCR
- PKD
- TSH Receptor
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- PKG
- CRFR
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- Imidazoline Receptor
- Bombesin Receptor
- RGS
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- Sigma Receptor
- Melanocortin Receptor
- PAR
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- NPY receptor
- Parathyroid Hormone Receptor
- DOCK
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- GPCR19
- Guanylate Cyclase
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- GRK
- Leukotriene
- FPR
- Prostaglandin Receptor
Endocrinology & Hormones
- Adrenergic Receptor
- 5-alpha Reductase
- Estrogen/progestogen Receptor
- Androgen Receptor
- RAAS
- Opioid Receptor
- Aromatase
- GPR
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- SSTR
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- THR
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Transmembrane Transporters
- CD markers
- Calcium Channel
- Sodium Channel
- ATPase
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- Potassium Channel
- GluR
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- P-gp
- Proton Pump
- CFTR
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- SGLT
- GLUT
- GlyT
- NMDAR
- OCT
- CRM1
- Amino acid transporter
- Mechanosensitive Channel
- OAT
- NKCC
- BCRP
- NCX
- OATP
- TRP Channel
- VRAC
- Aquaporin
- EAAT
- VDAC
- MTP
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Metabolism
- PPAR
- P450 (e.g. CYP17)
- HSP (HSP90)
- PDE
- Hydroxylase
- Factor Xa
- DHFR
- Aminopeptidase
- Dehydrogenase
- Procollagen C Proteinase
- Phospholipase (e.g. PLA)
- DPP
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- Phosphorylase
- Liver X Receptor
- FAAH
- Acyltransferase
- Retinoid Receptor
- Thioredoxin
- FXR
- Transferase
- Serine/threonin kinase
- CETP
- IDO/TDO
- phosphatase
- GLUT
- HMG-CoA Reductase
- Vitamin
- PKM
- Lipoxygenase
- FOX
- Lipase
- Fatty Acid Synthase
- LDL
- NAMPT
- Casein Kinase
- Decarboxylase
- Adenosine Deaminase
- Aldose Reductase
- CPSase
- Leukotriene
- Adenosine Kinase
- OXPHOS
- Glutathione
- Acetyl-CoA carboxylase
- Mitochondrial Metabolism
- Peroxidases
- SHIP
- PCSK9
- PGDS
- Mitochondrial pyruvate carrier
- PREP
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- Neprilysin
- RUNX
- FTO
- AdipoR
- PAD
- SREBP
- SCD
- CPT
- AP-1
- LDH
- Carbohydrate Metabolism
- CAR
- PAI-1
- γGCS
- SSTR
- ATP-citrate lyase
- FAO
- FTase
- SOD
- 3-MST
- GTPCH
- SGK
- GOT
- Serine hydrolase
- Epoxide Hydrolase
- glucocerebrosidase
- FABP
- Catalase
- THR
- ACSS2
- ROR
- Glucosylceramide Synthase
- ACE
- Thioredoxin Reductase
- PDHK
- PARG
- Xanthine Oxidase
- Mannosidase
- PGC-1α
Proteases
- HDAC
- Proteasome
- Caspase
- Aminopeptidase
- HCV Protease
- DPP
- HIV Protease
- MMP
- Thrombin
- Acyltransferase
- MALT
- Glutaminase
- Tyrosinase
- Serine Protease
- Cysteine Protease
- Cathepsin B
- PGDS
- Neprilysin
- SGK
- PREP
- GOT
- 3C-Like Protease
- PAD
- PCSK9
- Secretase
Microbiology
- HCV Protease
- Integrase
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- HIV Protease
- Anti-infection
- Influenza Virus
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- SARS-CoV
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- Parasite
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- Antiviral
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- 3C-Like Protease
- Antibiotics
- Enterovirus
- COVID-19
Others
- ADC Cytotoxin
- ADC Linker
- Drug-Linker Conjugates for ADC
- Antineoplastic and Immunosuppressive Antibiotics
- Selection Antibiotics for Transfected Cell
- Antibiotics for Mammalian Cell Culture
- Antibiotics for Plant Cell Culture
- Hydrotropic Agents
- Dyes
- PROTAC
- PROTAC Linker
- E3 ligase Ligand
- Target Protein Ligand
- Others
- Antibody-Drug Conjugate

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FOXM1

RNF112-mediated FOXM1 ubiquitination suppresses the proliferation and invasion of gastric cancer

485 views | Sep 27 2023

RNF112 suppresses gastric cancer progression by directly ubiquitinating FOXM1, making the RNF112/FOXM1 axis a potential prognostic biomarker and therapeutic target in gastric cancer. [Read the Full Post]

FOXM1 augments sorafenib resistance and promotes progression of hepatocellular carcinoma by epigenetically activating KIF23 expression

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The study revealed that upregulation of FOXM1 in hepatocellular carcinoma (HCC) cells contributes to sorafenib resistance and HCC progression by increasing the expression of KIF23, and targeting FOXM1 could be an effective treatment strategy for HCC. [Read the Full Post]