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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

GLUT

Iron Chelator VLX600 Inhibits Mitochondrial Respiration and Promotes Sensitization of Neuroblastoma Cells in Nutrition-Restricted Conditions

247 views | Sep 17 2023

The iron chelator VLX600 inhibits mitochondrial respiration, reduces MYCN/LMO1 expression, and induces cell death in neuroblastoma cells, regardless of MYCN status, suggesting its potential as a therapeutic agent in combination with conventional chemotherapy for the treatment of neuroblastoma. [Read the Full Post]

Enhanced chemotherapeutic efficacy of docetaxel in human lung cancer cell line via GLUT1 inhibitor

147 views | Aug 03 2023

The study demonstrated that co-administration of a GLUT1 inhibitor and docetaxel synergistically increased cytotoxicity and apoptosis in lung cancer cells, suggesting a promising therapeutic strategy for the treatment of lung cancer patients. [Read the Full Post]

Targeting of Glucose Transport and the NAD Pathway in Neuroendocrine Tumor (NET) Cells Reveals New Treatment Options

186 views | Jul 06 2023

In this study, the effectiveness of glucose transporter (GLUT) and nicotinamide phosphoribosyltransferase (NAMPT) inhibitors as potential treatments for neuroendocrine tumors (NET) was demonstrated through significant effects on tumor cell proliferation and survival rates. [Read the Full Post]

Investigations into the Signaling Pathways Involving Glucose-Stimulated Zinc Secretion (GSZS) from Prostate Epithelial Cells In Vitro and In Vivo

90 views | Jul 06 2023

Exposure of prostate cells to high glucose leads to glucose-stimulated zinc secretion (GSZS) both in vitro and in vivo, requiring glycolytic flux and involving the activation of specific signaling pathways. [Read the Full Post]

EgGLUT1 Is Crucial for the Viability of Echinococcus granulosus sensu stricto Metacestode: A New Therapeutic Target?

253 views | Apr 04 2022

Kuerbannisha Amahong et al. thought that EgGLUT1-ss was crucial for glucose uptake by the protoscoleces of E. granulosus s.s., and its inhibitor WZB117 had a therapeutic effect on CE. [Read the Full Post]

Involvement of GLUT1 and GLUT3 in the growth of canine melanoma cells

522 views | Apr 25 2021

Yoko Suwabe et al. suggested that glucose uptake via GLUT1 and GLUT3 played a crucial role for the growth of canine melanoma cells. [Read the Full Post]