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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

TLR

TLR8 aggravates skin inflammation and fibrosis by activating skin fibroblasts in systemic sclerosis

121 views | Nov 17 2023

The study demonstrates that Toll-like receptor 8 (TLR8) plays a pivotal role in promoting skin inflammation and fibrosis in systemic sclerosis (SSc), potentially offering a promising therapeutic target for improving SSc treatment strategies. [Read the Full Post]

Involvement of Abnormal p-α-syn Accumulation and TLR2-Mediated Inflammation of Schwann Cells in Enteric Autonomic Nerve Dysfunction of Parkinson's Disease: an Animal Model Study

84 views | Oct 17 2023

This study reveals that the accumulation of phosphorylated α-synuclein and Toll-like receptor 2 signaling in Schwann cells are implicated in disrupted gut homeostasis, highlighting the potential of targeting the TLR2-mediated pathway as a therapy for gastrointestinal dysfunction in Parkinson's disease. [Read the Full Post]

An injectable superior depot of Telratolimod inhibits post-surgical tumor recurrence and distant metastases

172 views | Sep 17 2023

The development of an injectable phase transition gel (PGE) for the delivery of Telratolimod (Tel) enhances the immunotherapeutic effects while reducing the risk of adverse effects, providing a clinically available option for effective postoperative combined therapy. [Read the Full Post]

5-FU mediated depletion of myeloid suppressor cells enhances T-cell infiltration and anti-tumor response in immunotherapy-resistant lung tumor

449 views | Jul 19 2023

Depletion of MDSCs using low-dose 5-fluorouracil (5-FU) chemotherapy showed significant anti-tumor effects by increasing the infiltration of CD8+ cytotoxic T-cells in a cold tumor model of Lewis Lung Carcinoma (LLC). [Read the Full Post]

Liver X Receptor Activation Attenuates Oxysterol-Induced Inflammatory Responses in Fetoplacental Endothelial Cells

230 views | Jun 11 2023

The study suggests that 7-ketocholesterol and 7β-hydroxycholesterol induce placental inflammation in gestational diabetes mellitus by activating TLR-4 and that pharmacological activation of LXR can attenuate the pro-inflammatory effects of these oxysterols in fetoplacental endothelial cells. [Read the Full Post]

TLR4 is one of the receptors for Chikungunya virus envelope protein E2 and regulates virus induced pro-inflammatory responses in host macrophages

256 views | Jun 11 2023

TLR4 inhibition using TAK-242 reduces CHIKV infection by decreasing viral copy number, CHIKV-E2 protein levels, and pro-inflammatory responses, highlighting TLR4 as a novel receptor involved in viral entry and modulation of infection-induced inflammation. [Read the Full Post]

Mutiple myeloma resistant to melphalan (NSC-8806) treated with cyclophosphamide (NSC-26271), prednisone (NSC-10023), and chloroquine (NSC-187208)

266 views | May 17 2023

This prospective randomized study compared the effectiveness of two therapeutic regimens in 41 patients with multiple myeloma resistant to melphalan, with no significant differences in response or toxicity observed between the groups, despite the addition of chloroquine to one regimen. [Read the Full Post]

A myeloid leukemia factor homolog is involved in tolerance to stresses and stress-induced protein metabolism in Giardia lamblia

252 views | May 16 2023

This study investigated the role of MLF vesicles in G. lamblia and found that they share similar stress-induced characteristics with autophagy compartments and are important for survival in stress conditions. [Read the Full Post]

Chronic Inhibition of Toll-Like Receptor 9 Ameliorates Pulmonary Hypertension in Rats

83 views | May 12 2023

TLR9 activation via the NF-κB‒IL-6 pathway contributes to the development of pulmonary hypertension and inhibition of TLR9 may serve as a promising therapeutic approach. [Read the Full Post]

Targeting TLR2/Rac1/cdc42/JNK Pathway to Reveal That Ruxolitinib Promotes Thrombocytopoiesis

94 views | May 09 2023

Ruxolitinib has been shown to facilitate megakaryocyte differentiation and maturation, leading to accelerated thrombocytopoiesis in radiation-injured thrombocytopenia mice, possibly via activation of the Rac1/cdc42/JNK pathway through binding to Toll Like Receptor 2 (TLR2). [Read the Full Post]