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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Mitochondrial Metabolism

Temporal landscape of mitochondrial proteostasis governed by the UPRmt

113 views | Jan 28 2024

The study elucidates the intricate network of mitochondrial proteostasis controlled by the unfolded protein response (UPRmt), showcasing its pivotal role in safeguarding and repairing damaged mitochondrial proteins, particularly emphasizing its impact on oxidative phosphorylation metabolism and its interplay with PINK1/Parkin-mediated mitophagy for cellular recovery during stress. [Read the Full Post]

Advances into Understanding the Vital Role of the Mitochondrial Citrate Carrier (CIC) in Metabolic Diseases

117 views | Oct 09 2023

This paper provides a comprehensive overview of the structure, function, and disease associations of the mitochondrial citrate carrier (CIC), highlighting its potential as a novel therapeutic target in a range of human metabolic diseases. [Read the Full Post]

Identifying responders to elamipretide in Barth syndrome: Hierarchical clustering for time series data

164 views | Sep 23 2023

This proof-of-concept study demonstrated that wearable device data can predict functional status and response to elamipretide treatment in patients with Barth syndrome (BTHS). [Read the Full Post]

Efficacy and Safety of Elamipretide in Individuals With Primary Mitochondrial Myopathy: The MMPOWER-3 Randomized Clinical Trial

270 views | Sep 23 2023

The MMPOWER-3 trial evaluating the efficacy of elamipretide in individuals with Primary Mitochondrial Myopathies did not show significant improvements in physical function and fatigue but established the drug's safety and tolerability. [Read the Full Post]

NDUFS3 knockout cancer cells and molecular docking reveal specificity and mode of action of anti-cancer respiratory complex I inhibitors

398 views | Jun 03 2023

This study highlights the need for cautious evaluation and dosage optimization of inhibitors targeting respiratory complex I in cancer treatment. [Read the Full Post]

Celastrol inhibits necroptosis by attenuating the RIPK1/RIPK3/MLKL pathway and confers protection against acute pancreatitis in mice

337 views | May 18 2023

Celastrol has been found to inhibit necroptosis by attenuating the phosphorylation of RIPK1, RIPK3, and MLKL and mitochondrial dysfunction in in vitro models, and in a mouse model of acute pancreatitis, it significantly reduced the severity of the disease and decreased the phosphorylation of MLKL in pancreatic tissues. [Read the Full Post]

Targeting mitochondrial stress with SS31 prevents experimental abdominal aortic aneurysm: crosstalk with ER stress

95 views | Apr 19 2023

The study demonstrates that inhibition of mitochondrial stress with SS31 limits AAA formation and increases survival through a reduction of vascular remodeling, inflammation, and ROS, and also supports the idea that the attenuation of ER stress contributes to the favorable response. [Read the Full Post]

Nogo-A Mediated Endoplasmic Reticulum Stress During Myocardial Ischemic-Reperfusion Injury in Diabetic Rats

85 views | Apr 19 2023

The study suggests that Nogo-A mediated ER stress plays a major role in diabetic MI/R injury, and pathologically altered Nogo-A expression mediates diabetic MI/R injury, suggesting Nogo-A as a potential target for the treatment of diabetic MI/R injury in clinical settings. [Read the Full Post]

Transplantation of autologous bone marrow pre-loaded ex vivo with oncolytic myxoma virus is efficacious against drug-resistant Vk*MYC mouse myeloma

241 views | Apr 05 2022

Nancy Y Villa et al. found the utility of autologous BM grafts armed ex vivo with oncolytic MYXV alone or in combination with chemotherapy/immunotherapy to treat drug-resistant MM in vivo. [Read the Full Post]

Loss of FADD and Caspases Affects the Response of T-Cell Leukemia Jurkat Cells to Anti-Cancer Drugs

551 views | Apr 26 2021

Zuzana Mrkvová et al. thought that a combination of TNF-α and smac mimetic could be a suitable strategy for overcoming resistance to therapy in cells unable to trigger apoptosis. [Read the Full Post]