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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

P450 (e.g. CYP17)

Supervised screening of Tecovirimat-like compounds as potential inhibitors for the monkeypox virus E8L protein

302 views | Dec 10 2023

The study utilized computational methods and machine learning-guided screening to identify five promising drugs, ABX-1431, Alflutinib, Avacopan, Caspitant, and Darapalib, which effectively engage the MPXV E8L surface binding protein with higher affinity than Tecovirimat, potentially offering new avenues for the development of personalized treatments for Monkeypox virus infections. [Read the Full Post]

Allelopathic Effect of Aqueous Extracts of Grass Genotypes on Eruca Sativa L

80 views | Dec 03 2023

The study investigates the allelopathic activity of fifty grass genotypes and identifies phenolic compounds, particularly caffeic acid, in Festulolium genotypes, demonstrating their potent inhibitory effect on the growth of Eruca sativa L., highlighting their potential for sustainable weed control in agriculture. [Read the Full Post]

Iron overload due to SLC40A1 mutation of type 4 hereditary hemochromatosis

212 views | Oct 30 2023

The reported case of hereditary hemochromatosis type 4B involving a SLC40A1 gene mutation was effectively treated with monthly red blood cell apheresis followed by oral deferasirox therapy. [Read the Full Post]

Lipid profile changes associated with antiretroviral therapies in a real-world cohort

84 views | Oct 21 2023

In this retrospective cohort study, treatment with elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide fumarate was associated with a significant worsening of the lipid profile compared to dolutegravir/abacavir/lamivudine, but no significant differences in cardiovascular events were observed between the two treatment groups. [Read the Full Post]

Abigene, a Prospective, Multicentric Study of Abiraterone Acetate Pharmacogenetics in Metastatic Castration-Resistant Prostate Cancer

179 views | Mar 21 2023

This study suggests that genetic variations in CYP17A1 and other androgen-related genes may help predict the efficacy and toxicity of abiraterone acetate treatment in advanced prostate cancer patients. [Read the Full Post]

Prospective role of 3βHSD1 in prostate cancer precision medicine

151 views | Mar 20 2023

3βHSD1 is both a promising therapeutic target and a predictive biomarker for prostate cancer, with the development of novel inhibitors and a better understanding of its regulatory mechanisms providing new opportunities for disease management. [Read the Full Post]

Blocking Cholesterol Metabolism with Tumor-Penetrable Nanovesicles to Improve Photodynamic Cancer Immunotherapy

298 views | Mar 17 2023

Researchers have designed matrix metalloproteinase-2-sensitive tumor-penetrable nanovesicles that can regulate cholesterol metabolism to enhance photodynamic cancer immunotherapy by reinvigorating the functions of CD8+ T cells and suppressing the migration of tumor cells. [Read the Full Post]

Sterol O-Acyltransferase Inhibition Ameliorates High-Fat Diet-Induced Renal Fibrosis and Tertiary Lymphoid Tissue Maturation after Ischemic Reperfusion Injury

183 views | Mar 17 2023

High-fat diet-induced renal tertiary lymphoid tissues and sustained inflammation in mice with ischemic reperfusion injury were found to be associated with sterol O-acyltransferase (SOAT) 1-dependent cholesteryl ester accumulation, and SOAT1 inhibition was found to attenuate TLT formation and renal inflammation, suggesting its potential as a therapeutic target for CKD prevention and treatment. [Read the Full Post]

Inclusion complex of ketoconazole and p-sulfonic acid calix[6]arene improves antileishmanial activity and selectivity against Leishmania amazonensis and Leishmania infantum

129 views | Feb 18 2023

An inclusion complex (IC6HKTZ) of ketoconazole and p-sulfonic acid calix[6]arene (CX6SO3H) was prepared to improve solubility and efficacy of ketoconazole against Leishmania amazonensis and Leishmania infantum, and results showed a 95-fold solubility enhancement and improved antileishmanial activities. [Read the Full Post]

Phytochemical Analysis, Antifungal, and Antioxidant Properties of Two Herbs ( Tristemma mauritianum and Crassocephalum bougheyanum) and One Tree ( Lavigeria macrocarpa) Species

222 views | Feb 17 2023

Tristemma mauritianum, Crassocephalum bougheyanum, and Lavigeria macrocarpa showed promising antifungal and antioxidant properties due to high phenolic, tannin, and flavonoid content, with T. mauritianum displaying the highest antifungal and antioxidant activities and a synergistic effect with ketoconazole against clinical resistant Candida isolates. [Read the Full Post]