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Acetyl-CoA carboxylase

Repurposing a tricyclic antidepressant in tumor and metabolism disease treatment through fatty acid uptake inhibition

80 views | Nov 12 2023

The study revealed that nortriptyline, an FDA-approved tricyclic antidepressant, inhibits fatty acid uptake by inducing lysosomal acidification and suppressing macropinocytosis, offering a potential strategy to control cellular fatty acid levels and address conditions such as tumor growth, lipogenesis, and hepatic steatosis. [Read the Full Post]