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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Bacterial

Clodronic Acid has Strong Inhibitory Interactions with the Urease Enzyme of Helicobacter Pylori: Computer-aided Design and in vitro Confirmation

115 views | Jan 13 2024

Clodronic acid's robust inhibition of Helicobacter pylori urease, supported by computational screening and in vitro assays, positions it as a promising candidate for repurposing into an efficient drug against H. pylori infection. [Read the Full Post]

Oridonin Synergistically Enhances the Pro-Apoptotic Effect of Venetoclax on Acute Myeloid Leukemia Cells by Inhibiting AKT Signaling

251 views | Nov 23 2023

**Synergistic inhibition of AKT signaling by oridonin enhances the apoptotic effects of venetoclax, offering a promising combination therapy to overcome resistance and improve outcomes in acute myeloid leukemia.** [Read the Full Post]

Novel targets and inhibitors of the Mycobacterium tuberculosis cytochrome bd oxidase to foster anti-tuberculosis drug discovery

92 views | Oct 15 2023

This review provides an overview of the structural, mechanistic, and inhibitory aspects of Mycobacterium tuberculosis cytochrome bd oxidase (cyt-bd), highlighting its potential as a target for the development of novel tuberculosis treatments. [Read the Full Post]

Solithromycin inhibits IL-13-induced goblet cell hyperplasia and MUC5AC, CLCA1, and ANO1 in human bronchial epithelial cells

127 views | Oct 10 2023

Solithromycin was found to attenuate IL-13-induced goblet cell hyperplasia and MUC5AC production by inhibiting the mRNA and protein expression of CLCA1 and ANO1, independent of STAT6 and ERK phosphorylation. [Read the Full Post]

Antibiotic Susceptibility Profile of Bacteria Causing Aerobic Vaginitis in Women in Iraq

218 views | Oct 06 2023

The study revealed high rates of antimicrobial resistance among bacterial isolates from women with aerobic vaginitis, with Gram-positive bacteria showing resistance to penicillins and cephalosporins and Gram-negative bacteria displaying resistance to multiple antibiotic classes. [Read the Full Post]

Proteasome Inhibition Sensitizes Liposarcoma to MDM2 Inhibition with Nutlin-3 by Activating the ATF4/CHOP Stress Response Pathway

266 views | Jul 03 2023

The study suggests that combining MDM2 inhibitors with proteasome inhibitors could improve the efficacy of treatment for liposarcoma by inducing apoptosis through activation of the ATF4/CHOP stress response axis. [Read the Full Post]

A large-scale functional analysis of genes expressed differentially in insulin secreting MIN6 sublines with high versus mildly reduced glucose-responsiveness

251 views | May 01 2023

This study identified 18 genes that altered glucose-stimulated insulin secretion (GSIS) in pancreatic β-cells, and confirmed Sox11 as a negative regulator of insulin secretion and its role in glucose metabolism. [Read the Full Post]

Tuberculosis: Pathogenesis, Current Treatment Regimens and New Drug Targets

219 views | Apr 30 2023

Tuberculosis (TB) caused by Mycobacterium tuberculosis is a global health concern that requires the development of new anti-TB drugs due to the emergence of drug-resistant strains and the challenges of current treatment protocols. [Read the Full Post]

Auranofin Targeting the NDM-1 Beta-Lactamase: Computational Insights into the Electronic Configuration and Quasi-Tetrahedral Coordination of Gold Ions

332 views | Apr 25 2023

Recent research has demonstrated that auranofin can restore penicillin and cephalosporin sensitivity in resistant bacterial strains via the inhibition of the NDM-1 beta-lactamase enzyme, accomplished through substituting gold for zinc in the enzyme's bimetallic core. [Read the Full Post]

Bacterial species and antimicrobial resistance differ between catheter and non-catheter-associated urinary tract infections: Data from a national surveillance network

102 views | Apr 19 2023

The study found that CAUTI pathogens were more often resistant to recommended empirical antibiotics than non-CAUTI pathogens, emphasizing the need for urine sampling for culturing before initiating therapy for CAUTI and the importance of considering therapeutic alternatives. [Read the Full Post]