Choose Your Country or Region

Category

PI3K/Akt/mTOR
- PI3K
- mTOR
- Akt
- GSK-3
- ATM/ATR
- PDK
- AMPK
- DNA-PK
- MELK
- PTEN
- PDPK1
- PP2A
- PIKfyve
- PI4K
Epigenetics
- HDAC
- AMPK
- PARP
- JAK
- Pim
- HIF
- PKC
- Aurora Kinase
- Sirtuin
- Histone Methyltransferase
- Histone Demethylase
- DNA Methyltransferase
- Histone Acetyltransferase
- Epigenetic Reader Domain
- DOT1
- HNMT
- SETD
- G9a/GLP
- NSD
- MLL
- FTO
- JMJD
- MicroRNA
- PRMT
- EZH1/2
- PAD
- LSD1
- COMT
- SAM MTase
- PPMTase
- WDR5
- SMYD
Methylation
- DNA Methyltransferase
- COMT
- SAM MTase
- PPMTase
- WDR5
- SMYD
- DOT1
- HNMT
- SETD
- G9a/GLP
- MLL
- JMJD
- PRMT
- NSD
- EZH1/2
- FTO
- LSD1
- MAT2A
- NNMT
Immunology & Inflammation
- CD markers
- PD-1/PD-L1
- TNF-alpha
- COX
- CCR
- Histamine Receptor
- IL Receptor
- TLR
- NOS
- Nrf2
- ROS
- NADPH-oxidase
- Anti-infection
- AhR
- gp120/CD4
- IDO/TDO
- CXCR
- NOD
- MALT
- LTR
- Immunology & Inflammation related
- IRAK
- FLAP
- Interleukins
- Arginase
- NLRP3
- Pyroptosis
- cGAS
- Neuraminidase
- SIK
- PGDS
- FKBP
- TRIF
- AKR1C
- PKR
- TpoR
- Parasite
- MmpL3
- Heme Oxygenase
- eIF
- Antioxidant
- MyD88
- MIF
- STING
- Nur77
- Galectin
- Complement System
- Prostaglandin Receptor
- Glutathione
- SPHK
- β-lactamase
- PGES
- TBK1
- IFN
Protein Tyrosine Kinase
- VEGFR
- MEK
- EGFR
- PDGFR
- c-Met
- HER2
- IGF-1R
- FLT3
- FGFR
- Bcr-Abl
- c-Kit
- Src
- ALK
- Syk
- Tie-2
- FAK
- c-RET
- DYRK
- Ephrin receptor
- ACK
- CSF-1R
- Trk receptor
- BTK
- RON
- Fer kinase
- ETK/BMX
- Mertk
- Axl
- Tyro3
- Pyk2
- ROS1
- DDR
Angiogenesis
- VEGFR
- JAK
- EGFR
- PDGFR
- HER2
- FLT3
- FGFR
- HIF
- VDA
- Bcr-Abl
- Src
- ALK
- Syk
- FAK
- BTK
Apoptosis
- PD-1/PD-L1
- STAT
- Bcl-2
- Caspase
- p53
- TNF-alpha
- MDM2/MDMX
- Survivin
- Ras
- c-RET
- IAP
- RIP kinase
- PERK
- ASK
- Ferroptosis
- Myc
- PKD
- PFKFB
- FKBP
- cytohesin
- Apoptosis related
- OXPHOS
- Heme Oxygenase
- TRADD
- Bcl-6
- Thymidylate Synthase
- Pyroptosis
- DAPK
- Nur77
Autophagy
- CXCR
- Nrf2
- LRRK2
- Autophagy
- OGA
- Beclin
- LC3
- cGAS
- ULK
- FKBP
- Mitophagy
- Heme Oxygenase
ER stress & UPR
- JNK
- HSP (HSP90)
- ROS
- PERK
- ASK
- eIF
- PKR
- Antioxidant
- ATF-6
- PDI
- IRE1
JAK/STAT
- JAK
- STAT
- EGFR
- Pim
MAPK
- S6 Kinase
- MEK
- Raf
- p38 MAPK
- JNK
- Ras
- TAK1
- ERK
- TOPK
- ASK
- Mixed Lineage Kinase
- MNK
- KLF
- MAP4K
- MAPKAPK2
Cytoskeletal Signaling
- Akt
- Bcr-Abl
- Wnt/beta-catenin
- PKC
- FAK
- HSP (HSP90)
- Kinesin
- ROCK
- Microtubule Associated
- MPS1
- Dynamin
- PAK
- Integrin
- Actin
- Cardiac Myosin
- PORCN
- TACC3
- MLCK
- Gap-Junction
Cell Cycle
- CDK
- DNA/RNA Synthesis
- PD-1/PD-L1
- Ras
- Aurora Kinase
- HSP (HSP90)
- Kinesin
- Chk
- ROCK
- Microtubule Associated
- DHFR
- PLK
- APC
- Wee1
- PERK
- TOPK
- Serine/threonin kinase
- Myc
- PAK
- Rho
- MPS1
- DYRK
- Casein Kinase
- PFKFB
- LIM kinase
- Mad2
- Haspin Kinase
- Choline kinase
- AP-1
- BMI-1
- DOCK
- p21
- FOXM1
- eIF
- Nur77
- TACC3
- PP2A
- RUNX
TGF-beta/Smad
- TGF-beta/Smad
- Bcr-Abl
- PKC
- ROCK
DNA Damage/DNA Repair
- HDAC
- ATM/ATR
- PARP
- DNA/RNA Synthesis
- PPAR
- MDM2/MDMX
- Sirtuin
- Topoisomerase
- DNA-PK
- DHFR
- Telomerase
- High-mobility Group
- DNA alkylator
- MTH1
- Casein Kinase
- RNR
- NUDIX
- eIF
- SMN
- Nucleoside Analog/Antimetabolite
- LIM kinase
- RAD51
- CRISPR/Cas9
- BMI-1
- Pax
- FENs
- OGG1
- Thymidylate Synthase
- G-quadruplex
Stem Cells & Wnt
- GSK-3
- JAK
- STAT
- TGF-beta/Smad
- Wnt/beta-catenin
- ROCK
- Hedgehog/Smoothened
- PKA
- Casein Kinase
- ERK
- Stemness kinase
- KLF
- OCT
- SFRP
- Fascin
- PORCN
- Notch
- Secretase
Hippo
- LATS
- TEAD
- MAP4K
- MST
- YAP
Ubiquitin
- Proteasome
- DUB
- p97
- E1 Activating
- SUMO
- E2 conjugating
- E3 Ligase
Neuronal Signaling
- Calcium Channel
- Beta Amyloid
- 5-HT Receptor
- COX
- GluR
- Adrenergic Receptor
- AChR
- Histamine Receptor
- Dopamine Receptor
- Opioid Receptor
- GABA Receptor
- P-gp
- P2 Receptor
- Cannabinoid Receptor
- OX Receptor
- CGRP Receptor
- MT Receptor
- MAO
- FAAH
- CaMK
- BACE
- Trk receptor
- GlyT
- NMDAR
- EAAT
- Neurokinin Receptor
- Notch
- Imidazoline Receptor
- Sigma Receptor
- NPY receptor
- Serotonin Transporter
- CCK receptor
- Neurotensin Receptor
- COMT
- Melanocortin Receptor
- Adenosine Deaminase
- TRP Channel
- Adenosine Kinase
- BChE
NF-κB
- HDAC
- NF-κB
- IκB/IKK
- MALT
- Nrf2
- ROS
- NOD
- AP-1
- Antioxidant
GPCR & G Protein
- Ras
- 5-HT Receptor
- CCR
- GluR
- Adrenergic Receptor
- AChR
- Histamine Receptor
- Dopamine Receptor
- Opioid Receptor
- GPR
- P2 Receptor
- Cannabinoid Receptor
- Endothelin Receptor
- S1P Receptor
- Hedgehog/Smoothened
- SGLT
- LPA Receptor
- OX Receptor
- CGRP Receptor
- MT Receptor
- PAFR
- PKA
- Adenosine Receptor
- Vasopressin Receptor
- cAMP
- CXCR
- CaSR
- TAAR
- Glucagon Receptor
- LTR
- Sigma Receptor
- Melanocortin Receptor
- PAR
- Taste Receptor
- NPY receptor
- Parathyroid Hormone Receptor
- DOCK
- AdipoR
- GPCR19
- Guanylate Cyclase
- GHSR
- CCK receptor
- Leukotriene
- FPR
- GRK
- Prostaglandin Receptor
- PKD
- TSH Receptor
- Neurokinin Receptor
- GNRH Receptor
- PKG
- CRFR
- Angiotensin Receptor
- Bradykinin Receptor
- Imidazoline Receptor
- Bombesin Receptor
- RGS
- Neurotensin Receptor
Endocrinology & Hormones
- Adrenergic Receptor
- 5-alpha Reductase
- Estrogen/progestogen Receptor
- Androgen Receptor
- RAAS
- Opioid Receptor
- Aromatase
- GPR
- Glucocorticoid Receptor
- PGES
- TSH Receptor
- GNRH Receptor
- PGDS
- Mineralocorticoid Receptor
- THR
- ACE
- SSTR
- GHSR
- CCK receptor
Transmembrane Transporters
- CD markers
- Calcium Channel
- Sodium Channel
- ATPase
- Chloride Channel
- Potassium Channel
- GluR
- AChR
- GABA Receptor
- P-gp
- Proton Pump
- CFTR
- P2 Receptor
- SGLT
- GlyT
- NMDAR
- OCT
- CRM1
- GLUT
- Aquaporin
- EAAT
- VDAC
- MTP
- VMAT
- GlyR
- MCT
- Amino acid transporter
- Mechanosensitive Channel
- OAT
- NKCC
- BCRP
- NCX
- OATP
- TRP Channel
- VRAC
Metabolism
- PPAR
- P450 (e.g. CYP17)
- HSP (HSP90)
- PDE
- Hydroxylase
- Factor Xa
- DHFR
- Aminopeptidase
- Dehydrogenase
- Procollagen C Proteinase
- Phospholipase (e.g. PLA)
- DPP
- Carbonic Anhydrase
- Phosphorylase
- Liver X Receptor
- FAAH
- Acyltransferase
- phosphatase
- GLUT
- HMG-CoA Reductase
- Vitamin
- PKM
- Lipoxygenase
- FOX
- Lipase
- Fatty Acid Synthase
- NAMPT
- LDL
- Casein Kinase
- Decarboxylase
- Retinoid Receptor
- Thioredoxin
- FXR
- Transferase
- Serine/threonin kinase
- CETP
- IDO/TDO
- AdipoR
- PAD
- SREBP
- SCD
- CPT
- LDH
- Carbohydrate Metabolism
- CAR
- AP-1
- PAI-1
- γGCS
- SSTR
- ATP-citrate lyase
- FAO
- FTase
- SOD
- 3-MST
- GTPCH
- SGK
- GOT
- Serine hydrolase
- Epoxide Hydrolase
- glucocerebrosidase
- FABP
- Catalase
- THR
- ACSS2
- ROR
- Glucosylceramide Synthase
- ACE
- Thioredoxin Reductase
- PDHK
- PARG
- Xanthine Oxidase
- Mannosidase
- PGC-1α
- Adenosine Deaminase
- Aldose Reductase
- CPSase
- Leukotriene
- Adenosine Kinase
- OXPHOS
- Glutathione
- Acetyl-CoA carboxylase
- Mitochondrial Metabolism
- Peroxidases
- SHIP
- PCSK9
- Mitochondrial pyruvate carrier
- PREP
- PGDS
- PP2A
- Neprilysin
- RUNX
- FTO
Proteases
- HDAC
- Proteasome
- Caspase
- Aminopeptidase
- HCV Protease
- DPP
- HIV Protease
- MMP
- Thrombin
- Acyltransferase
- Cysteine Protease
- MALT
- Glutaminase
- Tyrosinase
- Serine Protease
- Cathepsin B
- PGDS
- Neprilysin
- SGK
- PREP
- GOT
- 3C-Like Protease
- PAD
- PCSK9
- Secretase
Microbiology
- HCV Protease
- Integrase
- Reverse Transcriptase
- HIV Protease
- Anti-infection
- HBV
- HIV
- Fungal
- CMV
- Neuraminidase
- Parasite
- Thioredoxin Reductase
- Antiviral
- β-lactamase
- Bacterial
- Antibiotics
- 3C-Like Protease
- Enterovirus
- COVID-19
- Influenza Virus
- Ribosomal Peptidyl Transferase
- SARS-CoV
- RSV
- HPV
- HSV
- HCV
Others
- ADC Cytotoxin
- ADC Linker
- Drug-Linker Conjugates for ADC
- Antineoplastic and Immunosuppressive Antibiotics
- Selection Antibiotics for Transfected Cell
- Antibiotics for Mammalian Cell Culture
- Antibiotics for Plant Cell Culture
- Hydrotropic Agents
- Dyes
- PROTAC
- PROTAC Linker
- E3 ligase Ligand
- Target Protein Ligand
- Others
- Antibody-Drug Conjugate

DYRK

Targeting the survival kinase DYRK1B: A novel approach to overcome radiotherapy-related treatment resistance

109 views | Jan 09 2024

Targeting the stress-enhanced survival kinase DYRK1B alongside irradiation demonstrates a synergistic effect in eliminating colorectal tumor cells under harsh environmental stressors, offering a promising strategy to overcome treatment resistance. [Read the Full Post]

Active natural compounds perturb the melanoma risk-gene network

376 views | Jan 07 2024

The study ingeniously employs network modeling of melanoma-associated genes, revealing crucial pathways and potential therapeutic targets while showcasing the predictive potential of this model in evaluating the efficacy of anti-melanoma phytochemicals. [Read the Full Post]

Inhibitors of dual-specificity tyrosine phosphorylation-regulated kinases (DYRK) exert a strong anti-herpesviral activity

926 views | Nov 01 2018

Hutterer C et al. concluded that DYRK signaling represents a promising target pathway for the development of novel anti-herpesviral strategies. [Read the Full Post]

DYRK1B blocks canonical and promotes non-canonical Hedgehog signaling through activation of the mTOR/AKT pathway

1044 views | Oct 31 2018

Singh R et al. showed that a pharmacological approach combining a DYRK1B antagonist with an mTOR/AKT inhibitor results in strong GLI1 targeting and in pronounced cytotoxicity in human pancreatic and ovarian cancer cells. [Read the Full Post]