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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

S6 Kinase

AT7867 promotes pancreatic progenitor differentiation of human iPSCs

290 views | Jan 18 2024

AT7867 treatment significantly enhances the differentiation of pancreatic progenitor cells, resulting in increased expression of key markers and accelerated diabetes reversal upon transplantation into diabetic mice. [Read the Full Post]

Combination of RSK inhibitor LJH-685 and FLT3 inhibitor FF-10101 promoted apoptosis and proliferation inhibition of AML cell lines

129 views | Dec 31 2023

The synergistic effect of RSK inhibitor LJH-685 in combination with FLT3 inhibitor FF-10101 demonstrates promising therapeutic potential against FLT3-ITD mutated AML by targeting the MAPK-RSKs-YB-1 signaling pathway, offering new avenues for effective intervention in drug-resistant AML. [Read the Full Post]

Inhibition of DNA methylation attenuates lung ischemia-reperfusion injury after lung transplantation

220 views | Dec 11 2023

"Inhibition of DNA methylation, particularly through azathioprine treatment, attenuates lung ischemia-reperfusion injury by suppressing inflammation, oxidative stress, and endothelial dysfunction, highlighting its therapeutic potential for improving outcomes in lung transplantation." [Read the Full Post]

The Multikinase Inhibitor AD80 Induces Mitotic Catastrophe and Autophagy in Pancreatic Cancer Cells

361 views | Dec 10 2023

The study reveals that AD80, a multikinase inhibitor, exerts potent antineoplastic effects in pancreatic cancer cells by inducing mitotic aberrations, DNA damage, autophagy, and apoptosis, providing crucial insights into potential targeted therapeutic strategies for this deadly disease. [Read the Full Post]

Cell senescence-associated genes predict the malignant characteristics of glioblastoma

98 views | Dec 03 2023

The study identifies distinct molecular subtypes of glioblastoma based on cell senescence-associated gene expression patterns, develops a robust risk score model associated with patient prognosis and immunotherapy response, and suggests potential therapeutic strategies targeting specific pathways, highlighting the importance of personalized medicine in GBM treatment. [Read the Full Post]

Salmonella effector SopF regulates PANoptosis of intestinal epithelial cells to aggravate systemic infection

307 views | Apr 08 2023

The study demonstrates that SopF can attenuate intestinal inflammation and promote bacterial dissemination in mice infected with S. Typhimurium through a mechanism involving PDK1-RSK signaling that inhibits Caspase-8 activation and subverts PANoptosis. [Read the Full Post]

Staurosporine analogues from microbial and synthetic sources and their biological activities

496 views | Feb 20 2023

Staurosporine and its analogues have strong inhibitory effects against a variety of kinases and have various biological properties such as antifungal, antibacterial, and immunosuppressive activities, but have limited clinical effectiveness due to cross-reactivity and poor selectivity. [Read the Full Post]

A mitophagy-related gene signature associated with prognosis and immune microenvironment in colorectal cancer

549 views | Dec 24 2022

Cong Zhang et al. developed a novel mitophagy-related gene signature that could be utilized not only as an independent predictive biomarker but also as a tool for tailoring personalizing treatment for CRC patients. [Read the Full Post]

Safety and tolerability of bosutinib in patients with amyotrophic lateral sclerosis (iDReAM study): A multicentre, open-label, dose-escalation phase 1 trial

401 views | Dec 23 2022

Keiko Imamura et al. found that the treatment-responsive patients could be distinguished by lower levels of plasma NFL. [Read the Full Post]

Reactivation of cocaine contextual memory engages mechanistic target of rapamycin/S6 kinase 1 signaling

234 views | Dec 02 2022

Xiangdang Shi et al. thought that mTORC1 and p70S6K were required for reconsolidation of cocaine contextual memory. [Read the Full Post]