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SUMO

The therapeutic effect of glycyrrhizic acid compound ointment on imiquimod-induced psoriasis-like disease in mice

145 views | Jan 04 2024

The compound ointment containing glycyrrhetinic acid and herbal monomers exhibited superior efficacy in ameliorating Imiquimod-induced psoriasis-like symptoms in mice, significantly reducing inflammatory factors and demonstrating a stronger therapeutic effect compared to calcipotriol ointment. [Read the Full Post]

Ginkgolic acid inhibits the replication of pseudorabies virus in vitro and in vivo by suppressing the transcription of viral late genes

148 views | Nov 22 2023

Ginkgolic acid has been identified as a potent inhibitor of pseudorabies virus (PRV) replication by specifically suppressing the transcription of PRV late genes, offering a promising therapeutic avenue for combating PRV infections in the swine industry. [Read the Full Post]

SUMOylation of Rho-associated protein kinase 2 induces goblet cell metaplasia in allergic airways

60 views | Nov 07 2023

The study reveals that protein SUMOylation-mediated activation of ROCK2, facilitated by PIAS1 and involving Rho/ROCK signaling, is a key mechanism in the development of goblet cell metaplasia in allergic asthma, suggesting that targeting SUMOylation could be a potential therapeutic intervention for the disease. [Read the Full Post]

Protection of Regulatory T Cells from Fragility and Inactivation in the Tumor Microenvironment

238 views | Aug 29 2023

Downregulation of the IFNAR1 chain in intratumoral Treg cells, mediated by p38α kinase, protects them from fragility and maintains their immunosuppressive activities, while targeting sumoylation with the inhibitor TAK981 induces Treg fragility and inhibits tumor growth, offering potential therapeutic approaches for enhancing immunotherapies against cancer. [Read the Full Post]