Choose Your Country or Region

Category

PI3K/Akt/mTOR
- PI3K
- mTOR
- Akt
- GSK-3
- ATM/ATR
- PDK
- AMPK
- DNA-PK
- MELK
- PTEN
- PIKfyve
- PI4K
- PDPK1
- PP2A
Epigenetics
- HDAC
- AMPK
- PARP
- JAK
- Pim
- HIF
- PKC
- Aurora Kinase
- Sirtuin
- DNA Methyltransferase
- Histone Acetyltransferase
- Epigenetic Reader Domain
- Histone Methyltransferase
- Histone Demethylase
- SETD
- G9a/GLP
- NSD
- MLL
- FTO
- JMJD
- MicroRNA
- PRMT
- EZH1/2
- LSD1
- PAD
- COMT
- SAM MTase
- PPMTase
- WDR5
- SMYD
- DOT1
- HNMT
Methylation
- DNA Methyltransferase
- PRMT
- NSD
- EZH1/2
- FTO
- LSD1
- MAT2A
- NNMT
- COMT
- SAM MTase
- PPMTase
- WDR5
- SMYD
- DOT1
- HNMT
- SETD
- G9a/GLP
- MLL
- JMJD
Immunology & Inflammation
- CD markers
- PD-1/PD-L1
- TNF-alpha
- COX
- CCR
- Histamine Receptor
- IL Receptor
- gp120/CD4
- IDO/TDO
- CXCR
- NOD
- MALT
- LTR
- TLR
- NOS
- Nrf2
- ROS
- NADPH-oxidase
- Anti-infection
- AhR
- Immunology & Inflammation related
- TpoR
- Parasite
- MmpL3
- Heme Oxygenase
- eIF
- Antioxidant
- MyD88
- MIF
- STING
- Nur77
- Galectin
- Complement System
- Prostaglandin Receptor
- Glutathione
- SPHK
- β-lactamase
- PGES
- TBK1
- IFN
- IRAK
- FLAP
- Interleukins
- Arginase
- NLRP3
- Pyroptosis
- cGAS
- Neuraminidase
- SIK
- PGDS
- FKBP
- TRIF
- AKR1C
- PKR
Protein Tyrosine Kinase
- VEGFR
- MEK
- EGFR
- PDGFR
- c-Met
- HER2
- IGF-1R
- FLT3
- FGFR
- Bcr-Abl
- c-Kit
- Src
- ALK
- Syk
- Tie-2
- FAK
- c-RET
- Ephrin receptor
- ACK
- CSF-1R
- Trk receptor
- BTK
- DYRK
- RON
- Fer kinase
- ETK/BMX
- Mertk
- Axl
- Tyro3
- Pyk2
- ROS1
- DDR
Angiogenesis
- VEGFR
- JAK
- EGFR
- PDGFR
- HER2
- FLT3
- FGFR
- HIF
- VDA
- Bcr-Abl
- Src
- ALK
- Syk
- FAK
- BTK
Apoptosis
- PD-1/PD-L1
- STAT
- Bcl-2
- Caspase
- p53
- TNF-alpha
- MDM2/MDMX
- Survivin
- Ras
- c-RET
- IAP
- RIP kinase
- PERK
- ASK
- Ferroptosis
- Myc
- Thymidylate Synthase
- Pyroptosis
- DAPK
- Nur77
- PKD
- PFKFB
- cytohesin
- FKBP
- Apoptosis related
- OXPHOS
- Heme Oxygenase
- TRADD
- Bcl-6
Autophagy
- CXCR
- Nrf2
- LRRK2
- Autophagy
- ULK
- FKBP
- Mitophagy
- Heme Oxygenase
- OGA
- Beclin
- LC3
- cGAS
ER stress & UPR
- JNK
- HSP (HSP90)
- ROS
- PERK
- ASK
- eIF
- PKR
- Antioxidant
- ATF-6
- PDI
- IRE1
JAK/STAT
- JAK
- STAT
- EGFR
- Pim
MAPK
- S6 Kinase
- MEK
- Raf
- p38 MAPK
- JNK
- Ras
- TAK1
- ERK
- TOPK
- ASK
- Mixed Lineage Kinase
- MNK
- KLF
- MAP4K
- MAPKAPK2
Cytoskeletal Signaling
- Akt
- Bcr-Abl
- Wnt/beta-catenin
- PKC
- FAK
- HSP (HSP90)
- Kinesin
- ROCK
- Microtubule Associated
- MPS1
- Dynamin
- PAK
- Integrin
- Actin
- Cardiac Myosin
- PORCN
- TACC3
- Gap-Junction
- MLCK
Cell Cycle
- CDK
- DNA/RNA Synthesis
- PD-1/PD-L1
- Ras
- Aurora Kinase
- HSP (HSP90)
- Kinesin
- Chk
- ROCK
- Microtubule Associated
- DHFR
- PLK
- APC
- Wee1
- PERK
- TOPK
- Serine/threonin kinase
- Myc
- PAK
- Rho
- MPS1
- DYRK
- Casein Kinase
- PFKFB
- LIM kinase
- Mad2
- Haspin Kinase
- AP-1
- BMI-1
- Choline kinase
- p21
- DOCK
- eIF
- FOXM1
- Nur77
- TACC3
- PP2A
- RUNX
TGF-beta/Smad
- TGF-beta/Smad
- Bcr-Abl
- PKC
- ROCK
DNA Damage/DNA Repair
- HDAC
- ATM/ATR
- PARP
- DNA/RNA Synthesis
- PPAR
- MDM2/MDMX
- Sirtuin
- Topoisomerase
- DNA-PK
- DHFR
- Telomerase
- High-mobility Group
- DNA alkylator
- MTH1
- Casein Kinase
- NUDIX
- RNR
- eIF
- SMN
- Nucleoside Analog/Antimetabolite
- LIM kinase
- RAD51
- CRISPR/Cas9
- BMI-1
- Pax
- FENs
- OGG1
- Thymidylate Synthase
- G-quadruplex
Stem Cells & Wnt
- GSK-3
- JAK
- STAT
- TGF-beta/Smad
- Wnt/beta-catenin
- ROCK
- Hedgehog/Smoothened
- PKA
- Casein Kinase
- ERK
- Stemness kinase
- KLF
- OCT
- SFRP
- Fascin
- PORCN
- Notch
- Secretase
Hippo
- LATS
- TEAD
- MAP4K
- MST
- YAP
Ubiquitin
- Proteasome
- DUB
- p97
- E1 Activating
- SUMO
- E2 conjugating
- E3 Ligase
Neuronal Signaling
- Calcium Channel
- Beta Amyloid
- 5-HT Receptor
- COX
- GluR
- Adrenergic Receptor
- AChR
- Histamine Receptor
- Dopamine Receptor
- Opioid Receptor
- GABA Receptor
- P-gp
- P2 Receptor
- Cannabinoid Receptor
- OX Receptor
- CGRP Receptor
- MT Receptor
- MAO
- FAAH
- BACE
- Trk receptor
- GlyT
- NMDAR
- CaMK
- Notch
- Imidazoline Receptor
- Sigma Receptor
- NPY receptor
- CCK receptor
- Serotonin Transporter
- COMT
- Neurotensin Receptor
- Melanocortin Receptor
- TRP Channel
- Adenosine Deaminase
- Adenosine Kinase
- BChE
- EAAT
- Neurokinin Receptor
NF-κB
- HDAC
- NF-κB
- IκB/IKK
- MALT
- Nrf2
- ROS
- NOD
- Antioxidant
- AP-1
GPCR & G Protein
- Ras
- 5-HT Receptor
- CCR
- GluR
- Adrenergic Receptor
- AChR
- Histamine Receptor
- Dopamine Receptor
- Opioid Receptor
- GPR
- P2 Receptor
- Cannabinoid Receptor
- Endothelin Receptor
- S1P Receptor
- Hedgehog/Smoothened
- SGLT
- LPA Receptor
- OX Receptor
- CGRP Receptor
- MT Receptor
- PAFR
- PKA
- Vasopressin Receptor
- cAMP
- CXCR
- CaSR
- TAAR
- Glucagon Receptor
- LTR
- Adenosine Receptor
- CCK receptor
- Leukotriene
- FPR
- GRK
- Prostaglandin Receptor
- PKD
- TSH Receptor
- Neurokinin Receptor
- GNRH Receptor
- PKG
- CRFR
- Angiotensin Receptor
- Bradykinin Receptor
- Imidazoline Receptor
- Bombesin Receptor
- RGS
- Neurotensin Receptor
- Sigma Receptor
- Melanocortin Receptor
- PAR
- Taste Receptor
- NPY receptor
- Parathyroid Hormone Receptor
- DOCK
- AdipoR
- GPCR19
- Guanylate Cyclase
- GHSR
Endocrinology & Hormones
- Adrenergic Receptor
- 5-alpha Reductase
- Estrogen/progestogen Receptor
- Androgen Receptor
- RAAS
- Opioid Receptor
- Aromatase
- GPR
- Glucocorticoid Receptor
- Mineralocorticoid Receptor
- THR
- ACE
- SSTR
- GHSR
- CCK receptor
- PGES
- TSH Receptor
- GNRH Receptor
- PGDS
Transmembrane Transporters
- CD markers
- Calcium Channel
- Sodium Channel
- ATPase
- Chloride Channel
- Potassium Channel
- GluR
- AChR
- GABA Receptor
- P-gp
- Proton Pump
- CFTR
- P2 Receptor
- SGLT
- OCT
- CRM1
- GLUT
- GlyT
- NMDAR
- VDAC
- MTP
- VMAT
- GlyR
- MCT
- Amino acid transporter
- Mechanosensitive Channel
- OAT
- NKCC
- BCRP
- NCX
- OATP
- TRP Channel
- VRAC
- Aquaporin
- EAAT
Metabolism
- PPAR
- P450 (e.g. CYP17)
- HSP (HSP90)
- PDE
- Hydroxylase
- Factor Xa
- DHFR
- Aminopeptidase
- Dehydrogenase
- Procollagen C Proteinase
- Phospholipase (e.g. PLA)
- DPP
- Carbonic Anhydrase
- Phosphorylase
- Liver X Receptor
- FAAH
- Acyltransferase
- Fatty Acid Synthase
- NAMPT
- LDL
- Casein Kinase
- Decarboxylase
- Retinoid Receptor
- Thioredoxin
- FXR
- Transferase
- Serine/threonin kinase
- CETP
- IDO/TDO
- phosphatase
- GLUT
- HMG-CoA Reductase
- Vitamin
- PKM
- Lipoxygenase
- FOX
- Lipase
- Catalase
- THR
- ACSS2
- ROR
- Glucosylceramide Synthase
- ACE
- Thioredoxin Reductase
- PDHK
- PARG
- Xanthine Oxidase
- Mannosidase
- PGC-1α
- Adenosine Deaminase
- Aldose Reductase
- CPSase
- Leukotriene
- Adenosine Kinase
- OXPHOS
- Glutathione
- Acetyl-CoA carboxylase
- Mitochondrial Metabolism
- Peroxidases
- SHIP
- PCSK9
- Mitochondrial pyruvate carrier
- PREP
- PGDS
- PP2A
- Neprilysin
- RUNX
- FTO
- AdipoR
- PAD
- SREBP
- SCD
- CPT
- LDH
- Carbohydrate Metabolism
- CAR
- AP-1
- PAI-1
- γGCS
- SSTR
- ATP-citrate lyase
- FAO
- FTase
- SOD
- 3-MST
- GTPCH
- SGK
- GOT
- Serine hydrolase
- Epoxide Hydrolase
- glucocerebrosidase
- FABP
Proteases
- HDAC
- Proteasome
- Caspase
- Aminopeptidase
- HCV Protease
- DPP
- HIV Protease
- MMP
- Thrombin
- Acyltransferase
- Cysteine Protease
- MALT
- Glutaminase
- Tyrosinase
- Serine Protease
- Neprilysin
- SGK
- PREP
- GOT
- 3C-Like Protease
- PAD
- PCSK9
- Secretase
- Cathepsin B
- PGDS
Microbiology
- HCV Protease
- Integrase
- Reverse Transcriptase
- HIV Protease
- Anti-infection
- CMV
- Neuraminidase
- Parasite
- Thioredoxin Reductase
- Antiviral
- β-lactamase
- Bacterial
- 3C-Like Protease
- Antibiotics
- COVID-19
- Enterovirus
- Ribosomal Peptidyl Transferase
- Influenza Virus
- SARS-CoV
- RSV
- HPV
- HSV
- HCV
- HBV
- HIV
- Fungal
Others
- ADC Cytotoxin
- ADC Linker
- Drug-Linker Conjugates for ADC
- Antineoplastic and Immunosuppressive Antibiotics
- Selection Antibiotics for Transfected Cell
- Antibiotics for Mammalian Cell Culture
- Antibiotics for Plant Cell Culture
- Hydrotropic Agents
- Dyes
- PROTAC
- PROTAC Linker
- E3 ligase Ligand
- Target Protein Ligand
- Others
- Antibody-Drug Conjugate

Archives

Popular Post

ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

Neutrophil Extracellular Traps in Atherosclerosis and Thrombosis

by Selleckchem | Jan 30 2021

Despite effective therapeutic and preventive strategies, atherosclerosis and its complications still represent a substantial health burden. Leukocytes and inflammatory mechanisms are increasingly recognized as drivers of atherosclerosis. Neutrophil granulocytes within the circulation were recently shown to undergo neutrophil extracellular trap (NET) formation, linking innate immunity with acute complications of atherosclerosis. In this chapter, we summarize mechanisms of NET formation, evidence for their involvement in atherosclerosis and thrombosis, and potential therapeutic regimens specifically targeting NET components.

Related Products

Cat.No.	Product Name	Information
S8141	Cl-amidine	Cl-amidine is an irreversible pan-peptidylarginine deiminase (PAD) inhibitor with IC50 values of 5.9 ± 0.3 μM, 0.8 ± 0.3 μM, 6.2 ± 1.0 μM for PAD4, PAD1 and PAD3, respectively. Cl-amidine induces apoptosis.

Related Targets

PAD Immunology & Inflammation related Apoptosis related