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ER stress & UPR
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Cell Cycle
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TGF-beta/Smad
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DNA Damage/DNA Repair
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Stem Cells & Wnt
- GSK-3
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Hippo
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Ubiquitin
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NF-κB
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GPCR & G Protein
- Ras
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- PAFR
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- LTR
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- cAMP
- CXCR
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- TAAR
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- GNRH Receptor
- PKG
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- Angiotensin Receptor
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- Imidazoline Receptor
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- RGS
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- PAR
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- NPY receptor
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- DOCK
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- GPCR19
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- GHSR
- CCK receptor
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- FPR
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- Prostaglandin Receptor
- PKD
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Endocrinology & Hormones
- Adrenergic Receptor
- 5-alpha Reductase
- Estrogen/progestogen Receptor
- Androgen Receptor
- RAAS
- Opioid Receptor
- Aromatase
- GPR
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- SSTR
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- THR
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Transmembrane Transporters
- CD markers
- Calcium Channel
- Sodium Channel
- ATPase
- Chloride Channel
- Potassium Channel
- GluR
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- GABA Receptor
- P-gp
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- CFTR
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- SGLT
- GLUT
- GlyT
- NMDAR
- OCT
- CRM1
- Mechanosensitive Channel
- OAT
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- BCRP
- NCX
- OATP
- TRP Channel
- VRAC
- Aquaporin
- EAAT
- VDAC
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- VMAT
- GlyR
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- Amino acid transporter
Metabolism
- PPAR
- P450 (e.g. CYP17)
- HSP (HSP90)
- PDE
- Hydroxylase
- Factor Xa
- DHFR
- Aminopeptidase
- Dehydrogenase
- Procollagen C Proteinase
- Phospholipase (e.g. PLA)
- DPP
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- Phosphorylase
- Liver X Receptor
- FAAH
- Acyltransferase
- FXR
- Transferase
- Serine/threonin kinase
- CETP
- IDO/TDO
- phosphatase
- GLUT
- HMG-CoA Reductase
- Vitamin
- PKM
- Lipoxygenase
- FOX
- Lipase
- Fatty Acid Synthase
- NAMPT
- LDL
- Casein Kinase
- Decarboxylase
- Retinoid Receptor
- Thioredoxin
- Adenosine Kinase
- OXPHOS
- Glutathione
- Acetyl-CoA carboxylase
- Peroxidases
- SHIP
- PCSK9
- Mitochondrial Metabolism
- Mitochondrial pyruvate carrier
- PREP
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- CAR
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- γGCS
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- FAO
- FTase
- SOD
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- GTPCH
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- GOT
- Serine hydrolase
- Epoxide Hydrolase
- glucocerebrosidase
- FABP
- Catalase
- THR
- ACSS2
- ROR
- Glucosylceramide Synthase
- ACE
- Thioredoxin Reductase
- PDHK
- PARG
- Xanthine Oxidase
- Mannosidase
- PGC-1α
- Adenosine Deaminase
- Aldose Reductase
- CPSase
- Leukotriene
Proteases
- HDAC
- Proteasome
- Caspase
- Aminopeptidase
- HCV Protease
- DPP
- HIV Protease
- MMP
- Thrombin
- Acyltransferase
- Glutaminase
- Tyrosinase
- Serine Protease
- Cysteine Protease
- MALT
- Cathepsin B
- PGDS
- Neprilysin
- SGK
- PREP
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- 3C-Like Protease
- PCSK9
- PAD
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Microbiology
- HCV Protease
- Integrase
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- Anti-infection
- SARS-CoV
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- β-lactamase
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- Influenza Virus
- Ribosomal Peptidyl Transferase
Others
- ADC Cytotoxin
- ADC Linker
- Drug-Linker Conjugates for ADC
- Antineoplastic and Immunosuppressive Antibiotics
- Selection Antibiotics for Transfected Cell
- Antibiotics for Mammalian Cell Culture
- Antibiotics for Plant Cell Culture
- Hydrotropic Agents
- Dyes
- PROTAC
- PROTAC Linker
- E3 ligase Ligand
- Target Protein Ligand
- Others
- Antibody-Drug Conjugate

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The multifaceted roles of USP7: new therapeutic opportunities

by Selleckchem | Nov 25 2022

The deubiquitylating enzyme USP7 (HAUSP) sits at a critical node regulating the activities of numerous proteins broadly characterized as tumor suppressors, DNA repair proteins, immune responders, viral proteins, and epigenetic modulators. Aberrant USP7 activity may promote oncogenesis and viral disease making it a compelling target for therapeutic intervention. Disclosed drug discovery programs have identified inhibitors of USP7 such as P005091 with cellular proof of concept and anti-proliferative activity in cancer models. Taken together, USP7 inhibitors hold promise as a new strategy for the treatment of disease.

Related Products

Cat.No.	Product Name	Information
S7132	P5091	P5091 is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM and the closely related USP47.

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