TRPM4 gene variation associated with climatic conditions in Chinese cattle

The transient receptor potential (TRP) superfamily has been reported to play an important role in heat tolerance pathways. Based on the Bovine Genome Variation Database and Selective Signatures, a missense mutation (NC_037345.1: c.2237A > G: p. His746Arg) (rs209689836) was identified in the transient receptor potential cation channel subfamily M member 4 (TRPM4) gene, a member of the TRP family, corresponding to heat tolerance. Here, we explored the prevalence of this variant in 19 native Chinese cattle (comprised of 404 individuals) to determine its possible association with heat tolerance in Chinese cattle by using PCR and DNA sequencing. The distribution of alleles of NC_037345.1: c.2237A > G: p. His746Arg displays significant geographical differences across native Chinese cattle breeds, consistent with the distribution of indicine and taurine cattle in China. Additionally, the association analysis indicated that the G allele was significantly associated with mean annual temperature (T), relative humidity (RH) and temperature humidity index (THI) (p < .05), suggesting that cattle carrying allele G were distributed in regions with higher T, RH, and THI. In conclusion, our results suggested that the mutation of the TRPM4 gene in Chinese cattle might be a candidate locus associated with heat tolerance.

 

Comments：

The study investigated the prevalence of a missense mutation in the TRPM4 gene, which is a member of the TRP family that has been implicated in heat tolerance pathways. The authors examined 404 native Chinese cattle from 19 breeds and found that the distribution of alleles of the mutation showed significant geographical differences, which corresponded with the distribution of indicine and taurine cattle in China. The study also found that the G allele of the mutation was significantly associated with mean annual temperature, relative humidity, and temperature humidity index. This suggests that cattle carrying the G allele were more prevalent in regions with higher temperature, humidity, and THI, indicating that the mutation might be associated with heat tolerance in Chinese cattle.

Overall, the study provides valuable insights into the genetic basis of heat tolerance in cattle and identifies a potential candidate locus for further investigation. The findings could have important implications for the breeding and management of cattle in regions prone to high temperatures and humidity.

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