Home Blog of Signal Transduction Others Hydrotropic Agents Subchronic toxicity study of ferric oxide nanoparticles through intragastric administration: A 94-d, repeated dose study in Sprague Dawley rats

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Subchronic toxicity study of ferric oxide nanoparticles through intragastric administration: A 94-d, repeated dose study in Sprague Dawley rats

In this study, the toxicity of ferric oxide nanoparticles (Fe2O3 NPs) administered through gavage to Sprague Dawley (SD) rats for 94 d, consecutively and the recovery after Fe2O3 NPs withdrawal for 30 d were evaluated. The vehicle control group, low-, medium-, and high-dose groups were administered with the vehicle (0.5% sodium carboxymethyl cellulose [CMC-Na]), 125, 250, and 500 mg/kg of Fe2O3 NPs, respectively, administered every morning for 94 d. There was no significant difference in the body weight, food intake, hematological, blood biochemical, and urine indices of SD rats in each administration group and the control group (P > 0.05). There was no significant difference in organ weight, organ indices, and the coefficient of the visceral brain between the SD rats in the different dosage groups and the SD rats in the vehicle control group (P > 0.05). Histopathological observations showed that there was no correlation between the pathological lesions of the organs observed in this study and the dose of Fe2O3 NPs (P > 0.05). The no-observed-adverse-effect level (NOAEL) dose of Fe2O3 NPs was initially determined to be 500 mg/kg administered to SD rats through oral gavage for 94 d, consecutively, followed by recovery after Fe2O3 NPs withdrawal for 30 d.

 

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The study evaluated the toxicity of ferric oxide nanoparticles (Fe2O3 NPs) in Sprague Dawley (SD) rats administered through gavage for 94 days and the recovery after Fe2O3 NPs withdrawal for 30 days. The rats were divided into a vehicle control group, low, medium, and high dose groups, and were administered with the vehicle or different doses of Fe2O3 NPs every morning for 94 days. The study found that there were no significant differences in body weight, food intake, hematological, blood biochemical, and urine indices among the different administration groups and the control group. There were also no significant differences in organ weight, organ indices, and the coefficient of the visceral brain. Histopathological observations showed no correlation between the pathological lesions of the organs observed in the study and the dose of Fe2O3 NPs. The study concluded that the no-observed-adverse-effect level (NOAEL) dose of Fe2O3 NPs administered to SD rats through oral gavage for 94 days was 500 mg/kg, followed by recovery after Fe2O3 NPs withdrawal for 30 days.

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S6703 CMC-Na CMC-Na (Sodium carboxymethyl cellulose) is one of the important modified cellulose, a water-soluble cellulose, which is widely used in many application of food, pharmaceuticals, detergent, paper coating, dispersing agent, and others. Its addition possibly increases the hydrogenation and dehydrogenation features of Magnesium.

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