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PI3K/Akt/mTOR
- PI3K
- mTOR
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- GSK-3
- ATM/ATR
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- PDPK1
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Epigenetics
- HDAC
- AMPK
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- Pim
- HIF
- PKC
- Aurora Kinase
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- Histone Methyltransferase
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- SETD
- G9a/GLP
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- MLL
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- MicroRNA
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- COMT
- SAM MTase
- PPMTase
- WDR5
Methylation
- DNA Methyltransferase
- NNMT
- COMT
- SAM MTase
- PPMTase
- WDR5
- SMYD
- DOT1
- HNMT
- SETD
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- MLL
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- EZH1/2
- FTO
- LSD1
- MAT2A
Immunology & Inflammation
- CD markers
- PD-1/PD-L1
- TNF-alpha
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- Histamine Receptor
- IL Receptor
- LTR
- TLR
- NOS
- Nrf2
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- Anti-infection
- AhR
- IDO/TDO
- gp120/CD4
- NOD
- CXCR
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- Immunology & Inflammation related
- TBK1
- IFN
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- FLAP
- Interleukins
- Arginase
- NLRP3
- Pyroptosis
- cGAS
- Neuraminidase
- SIK
- PGDS
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- MmpL3
- Heme Oxygenase
- Antioxidant
- MyD88
- eIF
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- STING
- Nur77
- Galectin
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- Prostaglandin Receptor
- Glutathione
- SPHK
- β-lactamase
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Protein Tyrosine Kinase
- VEGFR
- MEK
- EGFR
- PDGFR
- c-Met
- HER2
- IGF-1R
- FLT3
- FGFR
- Bcr-Abl
- c-Kit
- Src
- ALK
- Syk
- Tie-2
- FAK
- c-RET
- DYRK
- Ephrin receptor
- ACK
- CSF-1R
- Trk receptor
- BTK
- DDR
- RON
- Fer kinase
- ETK/BMX
- Mertk
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- Tyro3
- Pyk2
- ROS1
Angiogenesis
- VEGFR
- JAK
- EGFR
- PDGFR
- HER2
- FLT3
- FGFR
- HIF
- VDA
- Bcr-Abl
- Src
- ALK
- Syk
- FAK
- BTK
Apoptosis
- PD-1/PD-L1
- STAT
- Bcl-2
- Caspase
- p53
- TNF-alpha
- MDM2/MDMX
- Survivin
- Ras
- c-RET
- IAP
- RIP kinase
- PERK
- ASK
- Ferroptosis
- Myc
- PKD
- PFKFB
- FKBP
- cytohesin
- Apoptosis related
- OXPHOS
- Heme Oxygenase
- TRADD
- Bcl-6
- Thymidylate Synthase
- Pyroptosis
- DAPK
- Nur77
Autophagy
- CXCR
- Nrf2
- LRRK2
- Autophagy
- OGA
- Beclin
- LC3
- cGAS
- ULK
- FKBP
- Mitophagy
- Heme Oxygenase
ER stress & UPR
- JNK
- HSP (HSP90)
- ROS
- PERK
- ASK
- eIF
- PKR
- Antioxidant
- ATF-6
- PDI
- IRE1
JAK/STAT
- JAK
- STAT
- EGFR
- Pim
MAPK
- S6 Kinase
- MEK
- Raf
- p38 MAPK
- JNK
- Ras
- KLF
- TAK1
- ERK
- TOPK
- ASK
- Mixed Lineage Kinase
- MNK
- MAP4K
- MAPKAPK2
Cytoskeletal Signaling
- Akt
- Bcr-Abl
- Wnt/beta-catenin
- PKC
- FAK
- HSP (HSP90)
- Kinesin
- ROCK
- Microtubule Associated
- Integrin
- MPS1
- Dynamin
- PAK
- Actin
- Cardiac Myosin
- PORCN
- TACC3
- MLCK
- Gap-Junction
Cell Cycle
- CDK
- DNA/RNA Synthesis
- PD-1/PD-L1
- Ras
- Aurora Kinase
- HSP (HSP90)
- Kinesin
- Chk
- ROCK
- Microtubule Associated
- DHFR
- PLK
- APC
- Wee1
- Casein Kinase
- PERK
- TOPK
- Serine/threonin kinase
- Myc
- PAK
- Rho
- MPS1
- DYRK
- RUNX
- PFKFB
- LIM kinase
- Mad2
- Haspin Kinase
- Choline kinase
- AP-1
- BMI-1
- DOCK
- p21
- FOXM1
- eIF
- Nur77
- TACC3
- PP2A
TGF-beta/Smad
- TGF-beta/Smad
- Bcr-Abl
- PKC
- ROCK
DNA Damage/DNA Repair
- HDAC
- ATM/ATR
- PARP
- DNA/RNA Synthesis
- PPAR
- MDM2/MDMX
- Sirtuin
- Topoisomerase
- DNA-PK
- DHFR
- Telomerase
- High-mobility Group
- DNA alkylator
- MTH1
- Casein Kinase
- RNR
- NUDIX
- eIF
- SMN
- Nucleoside Analog/Antimetabolite
- LIM kinase
- RAD51
- CRISPR/Cas9
- BMI-1
- Pax
- FENs
- OGG1
- Thymidylate Synthase
- G-quadruplex
Stem Cells & Wnt
- GSK-3
- JAK
- STAT
- TGF-beta/Smad
- Wnt/beta-catenin
- ROCK
- Hedgehog/Smoothened
- PKA
- OCT
- Casein Kinase
- ERK
- Stemness kinase
- KLF
- SFRP
- Fascin
- PORCN
- Notch
- Secretase
Hippo
- LATS
- TEAD
- MAP4K
- MST
- YAP
Ubiquitin
- Proteasome
- DUB
- p97
- E1 Activating
- SUMO
- E2 conjugating
- E3 Ligase
Neuronal Signaling
- Calcium Channel
- Beta Amyloid
- 5-HT Receptor
- COX
- GluR
- Adrenergic Receptor
- AChR
- Histamine Receptor
- Dopamine Receptor
- Opioid Receptor
- GABA Receptor
- P-gp
- P2 Receptor
- Cannabinoid Receptor
- OX Receptor
- CGRP Receptor
- MT Receptor
- MAO
- FAAH
- CaMK
- BACE
- Trk receptor
- GlyT
- NMDAR
- EAAT
- Neurokinin Receptor
- Notch
- Imidazoline Receptor
- Sigma Receptor
- NPY receptor
- Serotonin Transporter
- CCK receptor
- Neurotensin Receptor
- COMT
- Melanocortin Receptor
- Adenosine Deaminase
- TRP Channel
- Adenosine Kinase
- BChE
NF-κB
- HDAC
- NF-κB
- IκB/IKK
- MALT
- Nrf2
- ROS
- NOD
- AP-1
- Antioxidant
GPCR & G Protein
- Ras
- 5-HT Receptor
- CCR
- GluR
- Adrenergic Receptor
- AChR
- Histamine Receptor
- Dopamine Receptor
- Opioid Receptor
- GPR
- P2 Receptor
- Cannabinoid Receptor
- Endothelin Receptor
- S1P Receptor
- Hedgehog/Smoothened
- SGLT
- LPA Receptor
- OX Receptor
- CGRP Receptor
- MT Receptor
- PAFR
- PKA
- Adenosine Receptor
- Vasopressin Receptor
- cAMP
- CXCR
- TAAR
- CaSR
- Glucagon Receptor
- LTR
- RGS
- Neurotensin Receptor
- Sigma Receptor
- Melanocortin Receptor
- PAR
- Taste Receptor
- NPY receptor
- Parathyroid Hormone Receptor
- DOCK
- AdipoR
- GPCR19
- Guanylate Cyclase
- GHSR
- CCK receptor
- Leukotriene
- FPR
- GRK
- Prostaglandin Receptor
- PKD
- TSH Receptor
- Neurokinin Receptor
- GNRH Receptor
- PKG
- CRFR
- Angiotensin Receptor
- Bradykinin Receptor
- Imidazoline Receptor
- Bombesin Receptor
Endocrinology & Hormones
- Adrenergic Receptor
- 5-alpha Reductase
- Estrogen/progestogen Receptor
- Androgen Receptor
- RAAS
- Opioid Receptor
- Aromatase
- GPR
- Glucocorticoid Receptor
- PGES
- TSH Receptor
- GNRH Receptor
- PGDS
- Mineralocorticoid Receptor
- THR
- ACE
- SSTR
- GHSR
- CCK receptor
Transmembrane Transporters
- CD markers
- Calcium Channel
- Sodium Channel
- ATPase
- Chloride Channel
- Potassium Channel
- GluR
- AChR
- GABA Receptor
- P-gp
- Proton Pump
- CFTR
- P2 Receptor
- SGLT
- GLUT
- GlyT
- NMDAR
- OCT
- CRM1
- VRAC
- Aquaporin
- EAAT
- VDAC
- MTP
- VMAT
- GlyR
- MCT
- Amino acid transporter
- Mechanosensitive Channel
- OAT
- NKCC
- BCRP
- NCX
- OATP
- TRP Channel
Metabolism
- PPAR
- P450 (e.g. CYP17)
- HSP (HSP90)
- PDE
- Hydroxylase
- Factor Xa
- DHFR
- Aminopeptidase
- Dehydrogenase
- Procollagen C Proteinase
- Phospholipase (e.g. PLA)
- DPP
- Carbonic Anhydrase
- Phosphorylase
- Liver X Receptor
- FAAH
- Acyltransferase
- IDO/TDO
- phosphatase
- GLUT
- HMG-CoA Reductase
- Vitamin
- Lipoxygenase
- PKM
- Lipase
- FOX
- Fatty Acid Synthase
- NAMPT
- LDL
- Casein Kinase
- Decarboxylase
- Retinoid Receptor
- Thioredoxin
- FXR
- Transferase
- Serine/threonin kinase
- CETP
- RUNX
- FTO
- AdipoR
- PAD
- SREBP
- SCD
- CPT
- LDH
- Carbohydrate Metabolism
- CAR
- AP-1
- PAI-1
- γGCS
- SSTR
- ATP-citrate lyase
- FAO
- FTase
- SOD
- 3-MST
- GTPCH
- SGK
- GOT
- Serine hydrolase
- Epoxide Hydrolase
- glucocerebrosidase
- FABP
- Catalase
- THR
- ACSS2
- ROR
- Glucosylceramide Synthase
- ACE
- Thioredoxin Reductase
- PDHK
- Xanthine Oxidase
- Mannosidase
- PGC-1α
- PARG
- Aldose Reductase
- CPSase
- Leukotriene
- Adenosine Deaminase
- OXPHOS
- Glutathione
- Acetyl-CoA carboxylase
- Adenosine Kinase
- Peroxidases
- SHIP
- PCSK9
- Mitochondrial Metabolism
- Mitochondrial pyruvate carrier
- PREP
- PGDS
- PP2A
- Neprilysin
Proteases
- HDAC
- Proteasome
- Caspase
- Aminopeptidase
- HCV Protease
- DPP
- HIV Protease
- MMP
- Thrombin
- Acyltransferase
- Cysteine Protease
- MALT
- Glutaminase
- Tyrosinase
- Serine Protease
- Cathepsin B
- PGDS
- Neprilysin
- SGK
- GOT
- PREP
- 3C-Like Protease
- PCSK9
- PAD
- Secretase
Microbiology
- HCV Protease
- Integrase
- Reverse Transcriptase
- HIV Protease
- Anti-infection
- HCV
- HBV
- HIV
- Fungal
- CMV
- Neuraminidase
- Parasite
- Antiviral
- Thioredoxin Reductase
- Bacterial
- β-lactamase
- Antibiotics
- 3C-Like Protease
- Enterovirus
- COVID-19
- Influenza Virus
- Ribosomal Peptidyl Transferase
- SARS-CoV
- RSV
- HPV
- HSV
Others
- ADC Cytotoxin
- ADC Linker
- Drug-Linker Conjugates for ADC
- Antineoplastic and Immunosuppressive Antibiotics
- Selection Antibiotics for Transfected Cell
- Antibiotics for Mammalian Cell Culture
- Antibiotics for Plant Cell Culture
- Hydrotropic Agents
- Dyes
- PROTAC
- PROTAC Linker
- E3 ligase Ligand
- Target Protein Ligand
- Others
- Antibody-Drug Conjugate

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Partial response to dabrafenib and trametinib in relapsed BRAF V600E-Mutated multiple myeloma and possible mechanisms of resistance

by Selleckchem | Apr 18 2022

BRAF V600E mutations are detected in 3%-10% of patients with multiple myeloma (MM) and are associated with more aggressive disease, higher frequency of extramedullary growth and shorter survival. Monotherapy with the BRAF inhibitor vemurafenib has been disappointing in MM. In patients with BRAF-mutated melanoma, MEK and BRAF inhibition has been a successful approach. Here we describe a very good partial response and possible mechanisms of resistance to a combination of the BRAF inhibitor dabrafenib and the MEK inhibitor trametinib in a patient with BRAF V600E-mutant refractory MM.

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