Novel vesicular and particulate drug delivery systems for topical treatment of acne

Background: The efficacy of the antiacne topical drugs is well established. The local side effects, however, mainly cutaneous irritation, erythema, dryness, peeling and scaling, remain major problems. Novel vesicular and particulate drug delivery systems have been proposed to reduce the side effects of drugs commonly used in the topical treatment of acne.

Objective: This review focuses on the development and evaluation of antiacne drug-loaded vesicular and particulate delivery systems (liposomes, polymeric microspheres and solid lipid nanoparticles) for topical treatment, their advantages and challenges.

Methods: All the literature available was reviewed to highlight the potential of these novel systems for the topical treatment of acne.

Conclusion: The encapsulation of antiacne drugs in vesicular and particulate delivery systems represents an innovative alternative to minimize side effects, while preserving their efficacy. This can be obtained by the capacity of these systems to provide controlled release or to improve the drug penetration into skin or even into the pilosebaceous unit.

 

Comments:

Summary: The objective of this review is to discuss the development and evaluation of vesicular and particulate drug delivery systems for the topical treatment of acne. These systems include liposomes, polymeric microspheres, and solid lipid nanoparticles. The aim is to reduce the side effects commonly associated with antiacne drugs, such as cutaneous irritation, erythema, dryness, peeling, and scaling, while maintaining their effectiveness.

The review utilized available literature to assess the potential of these novel delivery systems in the treatment of acne. The encapsulation of antiacne drugs within vesicular and particulate systems offers several advantages. Firstly, these systems can provide controlled release of the drugs, allowing for a sustained and prolonged effect. Additionally, they can enhance the penetration of drugs into the skin and even into the pilosebaceous unit, which is the target site for acne treatment.

By utilizing these delivery systems, the aim is to minimize the side effects of antiacne drugs while ensuring their efficacy. This represents an innovative approach in the field of acne treatment, with the potential to improve patient outcomes and satisfaction.

Overall, this review emphasizes the potential benefits and challenges associated with vesicular and particulate drug delivery systems for topical antiacne treatment. The findings suggest that these novel approaches have promising prospects in improving the management of acne and reducing its associated side effects.

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Related Targets

Androgen Receptor