Multivariate Chemometric Comparison of Forced Degradation and Electrochemical Oxidation LC-MS Profiles of Maraviroc

In this study, nine forced degradation products of maraviroc were found using chemometric analysis. This antiretroviral drug was subjected to photolytic, oxidative, as well as neutral, basic and acidic hydrolysis stress conditions. Additionally, its electrochemical transformation on platinum, gold and glassy carbon screen-printed electrodes was examined. This study showed that maraviroc is especially susceptible to UVA, H2O2 and electrochemical degradation, while being resistant to neutral and acidic hydrolysis. A cluster analysis showed that the electrochemical transformation, with particular reference to the platinum electrode, is able to partially simulate the forced degradation processes, especially in the context of redox reactions. These findings indicate that the electrochemical methods can be considered as quick and relatively low-cost supplements to the commonly applied forced degradation procedures.

 

Comments：

The study conducted an analysis of the degradation products of maraviroc, an antiretroviral drug, under different stress conditions such as photolytic, oxidative, and hydrolysis. Additionally, the drug was tested for its electrochemical transformation on platinum, gold, and glassy carbon screen-printed electrodes. The study found that maraviroc was susceptible to UVA, H2O2, and electrochemical degradation, while being resistant to neutral and acidic hydrolysis.

The results of the study suggest that electrochemical methods can be used as a supplement to forced degradation procedures, as they provide quick and relatively low-cost alternatives to traditional methods. The study also highlights the potential of the electrochemical transformation method, especially on platinum electrodes, in simulating forced degradation processes, particularly in the context of redox reactions. Overall, these findings may be useful in improving the understanding of the degradation pathways of maraviroc and developing more efficient methods for drug development and quality control.

 

Related Products

Cat.No.	Product Name	Information
S2003	Maraviroc	Maraviroc is a CCR5 antagonist for MIP-1α, MIP-1β and RANTES with IC50 of 3.3 nM, 7.2 nM and 5.2 nM in cell-free assays, respectively. Maraviroc is used in the treatment of HIV infection.

Related Targets

HIV CCR