Mortality trends of aortic stenosis in high-income countries from 2000 to 2020

by Selleckchem | Jul 18 2023

Objective: The purpose of this study is to describe recent mortality trends from aortic stenosis (AS) among eight high-income countries.

Methods: We analysed the WHO mortality database to determine trends in mortality from AS in the UK, Germany, France, Italy, Japan, Australia, the USA and Canada from 2000 to 2020. Crude and age-standardised mortality rates per 100 000 persons were calculated. We calculated age-specific mortality rates in three groups (<64, 65-79 and ≥80 years). Annual percentage change was analysed using joinpoint regression.

Results: During the observation period, the crude mortality rates per 100 000 persons increased in all the eight countries (from 3.47 to 5.87 in the UK, from 2.98 to 8.93 in Germany, from 3.84 to 5.52 in France, from 1.97 to 4.33 in Italy, from 1.12 to 5.49 in Japan, from 2.14 to 3.38 in Australia, from 3.58 to 4.22 in the USA and from 2.12 to 5.00 in Canada). In joinpoint regression of age-standardised mortality rates, trend changes towards a decrease were observed in Germany after 2012 (-1.2%, p=0.015), Australia after 2011 (-1.9%, p=0.005) and the USA after 2014 (-3.1%, p<0.001). Age-specific mortality rates in age group ≥80 years had shifts towards decreasing trends in all the eight countries in contrast to other younger age groups.

Conclusions: While crude mortality rates increased in the eight countries, shifts towards decreasing trends were identified in age-standardised mortality rates in three countries and in the elderly aged ≥80 years in the eight countries. Further multidimensional observation is warranted to clarify the mortality trends.

Comments:

Abstract: This study aimed to examine recent mortality trends from aortic stenosis (AS) in eight high-income countries. Data from the WHO mortality database were analyzed to determine crude and age-standardized mortality rates per 100,000 persons from 2000 to 2020. Age-specific mortality rates were calculated for three age groups (<64, 65-79, and ≥80 years), and annual percentage change was assessed using joinpoint regression.

The findings showed that crude mortality rates per 100,000 persons increased in all eight countries during the study period. However, when analyzing age-standardized mortality rates, three countries exhibited trend changes towards a decrease: Germany after 2012, Australia after 2011, and the USA after 2014. Furthermore, age-specific mortality rates for individuals aged ≥80 years demonstrated decreasing trends in all eight countries, contrasting with other younger age groups.

In conclusion, while crude mortality rates rose in the examined countries, there were indications of decreasing trends in age-standardized mortality rates in three countries and among individuals aged ≥80 years across all eight countries. Further comprehensive observations are necessary to clarify these mortality trends.

Keywords: aortic stenosis, mortality trends, high-income countries, age-specific mortality rates, joinpoint regression.