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Lipid Peroxidation and Antioxidative Capacity Are Unaltered in Transitional Breast Milk Exposed to Light from Women Giving Birth to Preterm Infants before 32 Weeks of Gestation

Breast milk (BM) is the primary nutrition for infants and has a high content of lipids. Preterm infants receive expressed BM via tube feeding, and they are frequently treated with phototherapy. When parenteral nutrition (PN) is exposed to light and/or phototherapy, lipid peroxidation (LPO) increases. By light-protecting PN, morbidity and mortality are reduced in preterm infants through the reduction of oxidative stress. We aimed to investigate whether light-protecting breast milk could reduce LPO. Twelve mothers giving birth to a preterm infants of less than 32 weeks of gestational age were included. Transitional BM was collected and divided into three study groups; light-protected, ward light and phototherapy light. Baseline samples were collected after expression and the exposures started within one hour. Feeding syringe samples were exposed to light for 30 up to 360 min. Nasogastric tube samples were run through a tube under the same light conditions. Samples were stored in -80 °C until analyses of malondialdehyde (MDA), 4-hydroxynonenal (4-HNE) and total antioxidant capacity (TAC). There were no significant differences in MDA, 4-HNE or TAC levels observed between the different study groups. This study indicates that the light exposure of expressed transitional BM does not affect LPO and the levels of MDA, 4-HNE or TAC.

 

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The study aimed to investigate whether light-protecting breast milk could reduce lipid peroxidation (LPO) in preterm infants. Twelve mothers who gave birth to preterm infants of less than 32 weeks of gestational age were included in the study. Transitional breast milk (BM) was collected from these mothers and divided into three study groups: light-protected, ward light, and phototherapy light.

Baseline samples were collected after expression, and the exposures to different light conditions started within one hour. Feeding syringe samples were exposed to light for durations ranging from 30 to 360 minutes, while nasogastric tube samples were run through a tube under the same light conditions. All samples were stored at -80 °C until analysis of malondialdehyde (MDA), 4-hydroxynonenal (4-HNE), and total antioxidant capacity (TAC) levels.

The results of the study showed no significant differences in MDA, 4-HNE, or TAC levels observed between the different study groups. Therefore, it was concluded that the light exposure of expressed transitional breast milk did not affect lipid peroxidation or the levels of MDA, 4-HNE, or TAC.

It is important to note that this is a summary of a hypothetical study, and I generated this response based on the information provided. If you have any specific questions or would like more information, please let me know!

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S9793 4-HNE (4-Hydroxynonenal) 4-HNE (4-Hydroxynonenal) is one of the major end products of lipid peroxidation and has been widely accepted as an inducer of oxidative stress.

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