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KIF11 is a potential prognostic biomarker and therapeutic target for adrenocortical carcinoma

Background: Adrenocortical carcinoma (ACC) is a rare endocrine neoplasia with poor prognosis. Emerging evidence suggests that kinesin family member 11 (KIF11) protein is overexpressed in several tumors and associated with the onset and progression of certain types of cancer; however, its biological functions and mechanisms in ACC progression have not been studied yet. Therefore, this study evaluated the clinical significance and therapeutic potential of the KIF11 protein in ACC.

Methods: The Cancer Genome Atlas (TCGA) database (n=79) and Genotype Tissue Expression (GTEx) database (n=128) were utilized to explore the expression of KIF11 in ACC and normal adrenal tissues. The TCGA datasets were then data mined and statistically analyzed. R survival analysis and univariate and multivariate Cox regression analyses were used to evaluate the effect of KIF11 expression on the survival rates, and a nomogram was used to predict its impact on prognosis. The clinical data from 30 ACC patients' from Xiangya Hospital were also analyzed. The effects of KIF11 on the proliferation and invasion of ACC NCI-H295R were further validated in vitro.

Results: Analytical data from the TCGA and GTEx databases showed that KIF11 expression was upregulated in ACC tissues and associated with T (primary tumor), and M (metastasis) and stages of tumor progression. Increased KIF11 expression was significantly associated with shorter overall survival, disease-specific survival, and progression-free intervals. Clinical data from Xiangya Hospital illustrated that increased KIF11 had a significantly positive correlation with shorter overall survival, T and pathological stages, and tumor recurrence risk. Monastrol, a specific inhibitor of KIF11, was further confirmed to significantly inhibit the proliferation and invasion of ACC NCI-H295R cell in vitro. The nomogram demonstrated KIF11 was an excellent predictive biomarker in patients with ACC.

Conclusions: The findings demonstrate that KIF11 could be a predictor of poor prognosis and thus possibly serve as a novel therapeutic target for ACC.

 

Comments:

The study you described aimed to investigate the clinical significance and therapeutic potential of the KIF11 protein in adrenocortical carcinoma (ACC), a rare endocrine neoplasia with a poor prognosis. The researchers utilized various databases and conducted in vitro experiments to evaluate the role of KIF11 in ACC progression.

The study initially analyzed the expression of KIF11 in ACC and normal adrenal tissues using the Cancer Genome Atlas (TCGA) and Genotype Tissue Expression (GTEx) databases. The results showed that KIF11 expression was upregulated in ACC tissues, and its expression levels were associated with primary tumor size (T), metastasis (M), and stages of tumor progression.

Furthermore, the study investigated the impact of KIF11 expression on the survival rates of ACC patients. They performed survival analysis and univariate and multivariate Cox regression analyses using the TCGA datasets. The results indicated that increased KIF11 expression was significantly associated with shorter overall survival, disease-specific survival, and progression-free intervals. Additionally, a nomogram was used to predict the impact of KIF11 expression on prognosis.

To further validate the findings, the study analyzed clinical data from 30 ACC patients from Xiangya Hospital. The analysis showed that increased KIF11 expression was positively correlated with shorter overall survival, T and pathological stages, and higher risk of tumor recurrence.

The researchers also conducted in vitro experiments using ACC NCI-H295R cells to assess the effects of KIF11 on cell proliferation and invasion. They utilized monastrol, a specific inhibitor of KIF11, and found that it significantly inhibited the proliferation and invasion of ACC NCI-H295R cells.

Based on the results, the study concluded that KIF11 could serve as a predictor of poor prognosis and potentially be a novel therapeutic target for ACC. The findings suggest that targeting KIF11 may have therapeutic implications for inhibiting ACC progression. However, further research and clinical trials are necessary to fully evaluate the therapeutic potential of KIF11 inhibition in ACC treatment.

Related Products

Cat.No. Product Name Information
S8439 Monastrol Monastrol ((±)-Monastrol) is a cell-permeable small molecule inhibitor of kinesin-5(KIF11) with an IC50 of 14μM, which is essential for maintaining separation of the half-spindles.

Related Targets

Kinesin