Immunostimulatory effects of dairy probiotic strains Bifidobacterium animalis ssp. lactis HY8002 and Lactobacillus plantarum HY7717

Previous studies reported that Bifidobacterium animalis ssp. lactis HY8002 (HY8002) improved intestinal integrity and had immunomodulatory effects. Lactobacillus plantarum HY7717 (HY7717) was screened in vitro from among 21 other lactic acid bacteria (LAB) and demonstrated nitric oxide (NO) production. The aims of this study were to investigate the individual and combined ex vivo and in vivo effects of LAB strains HY8002 and HY7717 at immunostimulating mice that have been challenged with an immunosuppressant drug. The combination of HY8002 and HY7717 increased the secretion of cytokines such as interferon (IFN)-γ, interleukin (IL)-12, and tumor necrosis factor (TNF)-α in splenocytes. In a cyclophosphamide (CTX)-induced immunosuppression model, administration of the foregoing LAB combination improved the splenic and hematological indices, activated natural killer (NK) cells, and up-regulated plasma immunoglobulins and cytokines. Moreover, this combination treatment increased Toll-like receptor 2 (TLR2) expression. The ability of the combination treatment to upregulate IFN-γ and TNF-α in the splenocytes was inhibited by anti-TLR2 antibody. Hence, the immune responses stimulated by the combination of HY8002 and HY7717 are associated with TLR2 activation. The preceding findings suggest that the combination of the HY8002 and HY7717 LAB strains could prove to be a beneficial and efficacious immunostimulant probiotic supplement. The combination of the two probiotic strains will be applied on the dairy foods including yogurt and cheese.

 

Comments：

The study investigated the individual and combined effects of two LAB strains, HY8002 and HY7717, on immune stimulation in mice challenged with an immunosuppressant drug. The combination of HY8002 and HY7717 increased the secretion of cytokines and activated natural killer cells, upregulated plasma immunoglobulins and cytokines, and improved splenic and hematological indices in a CTX-induced immunosuppression model.

Furthermore, the combination treatment increased Toll-like receptor 2 (TLR2) expression, and the immune responses stimulated by the combination were associated with TLR2 activation. The study suggests that the combination of HY8002 and HY7717 LAB strains could be a beneficial and efficacious immunostimulant probiotic supplement.

It is also mentioned that the combination of the two probiotic strains will be applied to dairy foods, including yogurt and cheese. This suggests the potential use of these strains as food additives for their immune-stimulating effects.

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