Home Blog of Signal Transduction GPCR & G Protein Hedgehog/Smoothened Giant Basal Cell Carcinoma of the Axilla: 8-year Follow-up of a Case Treated with Excision, Vismodegib, and Radiotherapy

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Giant Basal Cell Carcinoma of the Axilla: 8-year Follow-up of a Case Treated with Excision, Vismodegib, and Radiotherapy

xillary giant basal cell carcinoma is extremely rare and remains challenging for physicians. The few reported cases have a relatively short-term follow-up, and none were treated with an oral hedgehog pathway inhibitor. Herein, we report the case of a 71-year-old man with a giant basal cell carcinoma in the axilla. The primary treatment instituted was surgical excision and adjuvant radiotherapy. The tumor recurred 4.5 years later, and 6-month treatment with vismodegib, a hedgehog pathway inhibitor, was effective. The disease progression re-occurred 1.5 years after discontinuing vismodegib. Palliative radiotherapy was administered, and the disease remained stable for > 1 year. Our case illustrates a rare disease with an 8-year follow-up, involving different therapeutic strategies against multiple recurrences.

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Cat.No. Product Name Information
S1082 Vismodegib (GDC-0449) Vismodegib (GDC-0449) is a potent, novel and specific hedgehog inhibitor with IC50 of 3 nM and also inhibits P-gp with IC50 of 3.0 μM in a cell-free assay.

Related Targets

Hedgehog/Smoothened