Home Blog of Signal Transduction DNA Damage/DNA Repair DNA alkylator Effect of maca (Lepidium meyenii) extract on non-obstructive azoospermia in male mice

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Effect of maca (Lepidium meyenii) extract on non-obstructive azoospermia in male mice

Ethnopharmacological relevance: Maca (Lepidium meyenii) is a medicinal and edible plant that has a long history attention because of its potential to improve fertility and sexual function.

Aim of study: In this study, effects of maca on azoospermia were investigated. The effective components of maca were screened.

Materials and methods: The therapeutic action of maca were evaluated in a busulfan-induced azoospermic model.

Results: It was found that maca could alleviate the vacuolation of spermatogenic tubules and testicular lesions, promote the recovery of spermatogenic epithelium, inhibit the proliferation of stromal cells, significantly increase the serum testosterone content, and improve the number and quality of sperm. Maca extract was then divided into polysaccharides, oligosaccharides and small molecules fractions for preliminary screening of efficacy. These results showed that there was no significant difference between the maca polysaccharide fraction and maca extract.

Conclusions: The results were shown that maca can improve non-obstructive azoospermia, the polysaccharide fraction was the active components.

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The study investigated the effects of maca on azoospermia and screened for its active components. Results showed that maca could improve non-obstructive azoospermia by alleviating testicular lesions, promoting recovery of spermatogenic epithelium, increasing testosterone levels, and improving the number and quality of sperm. The polysaccharide fraction was identified as the active component.

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Cat.No. Product Name Information
S1692 Busulfan Busulfan is a cell cycle non-specific alkylating antineoplastic agent. It causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase activity. It also induces apoptosis. It is an immunosuppressive and myeloablative chemotherapeutic agent.Busulfan (NSC-750) can be used to induce animal models of Anemia.

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Apoptosis related DNA alkylator