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Effect of hyperthermia alone and in combination with anticancer drugs on the viability of P388 leukemic cells

Effect of local tumor hyperthermia (42 degrees C) at various intervals ranging from 1 to 5 h and in combination with antineoplastic drugs was investigated on P388 murine lymphocytic leukemic cells by using an in vitro-in vivo bioassay method. It was observed that a 1-h exposure resulted in a one log cell kill. In combination studies with hyperthermia and anticancer drugs, 1-h exposure to hyperthermia along with 10 micrograms/ml in vitro concentration of adriamycin (NSC 23127), vincristine (NSC 67574), or 5-fluorouracil (NSC 19893) resulted in the synergistic cell killing action against P388 leukemic cells. However, cyclophosphamide (NSC 26271) and cytosine arabinoside (NSC 63878) did not show any enhanced therapeutic effect.

 

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An investigation into the effects of local tumor hyperthermia at 42°C combined with antineoplastic drugs found that a 1-hour exposure resulted in a one-log cell kill, with a synergistic cell killing effect against P388 leukemic cells when combined with adriamycin, vincristine, or 5-fluorouracil, but no enhanced effect with cyclophosphamide or cytosine arabinoside.

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