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TGF-beta/Smad
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Stem Cells & Wnt
- GSK-3
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Hippo
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Ubiquitin
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NF-κB
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GPCR & G Protein
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- PAFR
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Endocrinology & Hormones
- Adrenergic Receptor
- 5-alpha Reductase
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Transmembrane Transporters
- CD markers
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- GluR
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Metabolism
- PPAR
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- FAAH
- Acyltransferase
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- Vitamin
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- Lipoxygenase
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- Fatty Acid Synthase
- LDL
- NAMPT
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- CETP
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- ACE
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- PDHK
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- Xanthine Oxidase
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- PGC-1α
- Adenosine Deaminase
- Aldose Reductase
- CPSase
- Leukotriene
- Adenosine Kinase
- OXPHOS
- Glutathione
- Acetyl-CoA carboxylase
- Mitochondrial Metabolism
- Peroxidases
- SHIP
- PCSK9
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- PREP
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Proteases
- HDAC
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- MMP
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Microbiology
- HCV Protease
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- Anti-infection
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Others
- ADC Cytotoxin
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- Antineoplastic and Immunosuppressive Antibiotics
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- Hydrotropic Agents
- Dyes
- PROTAC
- PROTAC Linker
- E3 ligase Ligand
- Target Protein Ligand
- Others
- Antibody-Drug Conjugate

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Cyclopamine: from cyclops lambs to cancer treatment

by Selleckchem | Mar 01 2019

In the late 1960s, the steroidal alkaloid cyclopamine was isolated from the plant Veratrum californicum and identified as the teratogen responsible for craniofacial birth defects including cyclops in the offspring of sheep grazing on mountain ranges in the western United States. Cyclopamine was found to inhibit the hedgehog (Hh) signaling pathway, which plays a critical role in embryonic development. More recently, aberrant Hh signaling has been implicated in several types of cancer. Thus, inhibitors of the Hh signaling pathway, including cyclopamine derivatives, have been targeted as potential treatments for certain cancers and other diseases associated with the Hh signaling pathway. A brief history of cyclopamine and cyclopamine derivatives investigated for the treatment of cancer is presented.

Related Products

Cat.No.	Product Name	Information
S1146	Cyclopamine	Cyclopamine (11-deoxojervine) is a specific Hedgehog (Hh) signaling pathway antagonist of Smoothened (Smo) with IC50 of 46 nM in TM3Hh12 cells.

Related Targets

Hedgehog/Smoothened