[Chinese multidisciplinary expert consensus on the management of adverse drug reactions associated with savolitinib]

by Selleckchem | Jun 22 2023

MET gene is a proto-oncogene, which encodes MET protein with tyrosine kinase activity. After binding to its ligand, hepatocyte growth factor, MET protein can induce MET dimerization and activate downstream signaling pathways, which plays a crucial role in tumor formation and metastasis. Savolitinib, as a specific tyrosine kinase inhibitor (TKI) targeting MET, selectively inhibits the phosphorylation of MET kinase with a significant inhibitory effect on tumors with MET abnormalities. Based on its significant efficacy shown in the registration studies, savolitinib was approved for marketing in China on June 22, 2021 for the treatment of advanced non-small cell lung cancer with MET 14 exon skipping mutations. In addition, many studies have shown that MET TKIs are equally effective in patients with advanced solid tumors with MET gene amplification or MET protein overexpression, and relevant registration clinical studies are ongoing. The most common adverse reactions during treatment with savolitinib include nausea, vomiting, peripheral edema, pyrexia, and hepatotoxicity. Based on two rounds of extensive nationwide investigations to guide clinicians, the consensus is compiled to use savolitinib rationally, prevent and treat various adverse reactions scientifically, and improve the clinical benefits and quality of life of patients. This consensus was prepared under the guidance of multidisciplinary experts, especially including the whole-process participation and valuable suggestions of experts in Traditional Chinese Medicine, thus reflecting the clinical treatment concept of integrated Chinese and western medicines.

Comments:

The information you provided describes the role of the MET gene and its protein product, MET, in cancer development and metastasis. It also highlights savolitinib, a specific tyrosine kinase inhibitor (TKI) targeting MET, as an approved treatment for advanced non-small cell lung cancer with MET 14 exon skipping mutations in China.

Savolitinib selectively inhibits the phosphorylation of MET kinase, thereby inhibiting downstream signaling pathways involved in tumor growth and metastasis. The drug has shown significant efficacy in registration studies, leading to its approval for marketing in China.

Clinical studies have also demonstrated the effectiveness of MET TKIs in patients with advanced solid tumors exhibiting MET gene amplification or MET protein overexpression. Ongoing registration clinical studies are further exploring the use of MET TKIs in these patient populations.

Like many medications, savolitinib can cause adverse reactions. The most common adverse reactions associated with its use include nausea, vomiting, peripheral edema, pyrexia (fever), and hepatotoxicity (liver toxicity).

To ensure the rational use of savolitinib and effectively manage adverse reactions, two rounds of extensive nationwide investigations have been conducted to provide guidance to clinicians. This consensus, prepared under the guidance of multidisciplinary experts, emphasizes the integration of Chinese and Western medicine in clinical treatment, with valuable input from experts in Traditional Chinese Medicine.

It's important to note that while I can provide information based on available knowledge up until September 2021, it's always advisable to consult up-to-date sources, medical professionals, and official guidelines for the most recent information regarding specific drugs and treatments.