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Bestatin, A Pluripotent Immunomodulatory Small Molecule, Drives Robust and Long-Lasting Immune Responses as an Adjuvant in Viral Vaccines

An inactivated whole-virus vaccine is currently used to prevent foot-and-mouth disease (FMD). Although this vaccine is effective, it offers short-term immunity that requires regular booster immunizations and has several side effects, including local reactions at the vaccination site. To address these limitations, herein, we evaluated the efficacy of bestatin as a novel small molecule adjuvant for inactivated FMD vaccines. Our findings showed that the FMD vaccine formulated with bestatin enhanced early, intermediate-, and particularly long-term immunity in experimental animals (mice) and target animals (pigs). Furthermore, cytokines (interferon (IFN)α, IFNβ, IFNγ, and interleukin (IL)-29), retinoic acid-inducible gene (RIG)-I, and T-cell and B-cell core receptors (cluster of differentiation (CD)28, CD19, CD21, and CD81) markedly increased in the group that received the FMD vaccine adjuvanted with bestatin in pigs compared with the control. These results indicate the significant potential of bestatin to improve the efficacy of inactivated FMD vaccines in terms of immunomodulatory function for the simultaneous induction of potent cellular and humoral immune response and a long-lasting memory response.

 

Comments:

It sounds like the research on bestatin as an adjuvant for inactivated foot-and-mouth disease (FMD) vaccines is quite promising! Adjuvants like bestatin are substances added to vaccines to enhance the body's immune response. Your findings suggest that when bestatin is included in the FMD vaccine, it significantly boosts the immune system's response in both mice and pigs.

The observed increase in various cytokines (IFNα, IFNβ, IFNγ, IL-29) and immune receptors (RIG-I, CD28, CD19, CD21, CD81) indicates that bestatin helps stimulate a robust immune reaction. This enhanced immune response is crucial for developing both cellular and humoral immunity, which could potentially lead to a longer-lasting and more effective defense against FMD.

The ability of bestatin to improve the vaccine's efficacy is noteworthy, especially with the potential for longer-term immunity and a stronger memory response. If further validated, this could pave the way for developing more effective FMD vaccines with fewer side effects and a longer duration of protection.

Related Products

Cat.No. Product Name Information
S1591 Bestatin (Ubenimex) Bestatin (Ubenimex) is a potent aminopeptidase-B and leukotriene (LT) A4 hydrolase inhibitor, used in the treatment of acute myelocytic leukemia.

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