ADME Prediction, Structure-activity Relationship of Boswellic Acid Scaffold for the Aspect of Anticancer & Anti-inflammatory Potency

by Selleckchem | Oct 22 2023

Nature is the chief source of various remedies which are used to cure various diseases. Boswellic acid (BA) is a secondary metabolite from the pentacyclic terpenoid compound groups that are derived from the plant genus Boswellia. The oleo gum resins of these plants are primarily composed of polysaccharides, with the remaining amounts of resin (30-60%) and essential oils (5-10%) soluble in organic solvents. BA and its analogs are also reported to exhibit various in-vivo and biological responses for example anti-inflammatory, anti-tumor, free radical scavenging activity, etc. Among all analogs, 11-keto-β-boswellic acid (KBA) and 3-O-acetyl-11-keto-β-boswellic acid (AKBA) has been demonstrated to be the most effective at reducing cytokine production and inhibiting the inflammatory responsecausing enzymes. In this review, we summarized the computational ADME prediction via the SwissADME computational tool and the structure-activity relationship of the Boswellic acid scaffold for the aspect of anticancer and antiinflammatory potency. In addition to these research findings which are associated with the therapy of acute inflammation and some cancers, the potential of boswellic acids against other disorders was also discussed.

Comments:

Boswellic acid (BA) is a secondary metabolite derived from the plant genus Boswellia. The plants produce oleo gum resins composed mainly of polysaccharides, with smaller amounts of resin and essential oils. BA and its analogs have shown various in-vivo and biological responses, including anti-inflammatory, anti-tumor, and free radical scavenging activities.

Among the analogs, 11-keto-β-boswellic acid (KBA) and 3-O-acetyl-11-keto-β-boswellic acid (AKBA) have demonstrated the highest effectiveness in reducing cytokine production and inhibiting inflammatory response-causing enzymes. These compounds have been studied for their therapeutic potential in acute inflammation and certain types of cancer.

To explore the potential of boswellic acids further, computational ADME (absorption, distribution, metabolism, and excretion) prediction was performed using the SwissADME computational tool. This tool helps in predicting the pharmacokinetic properties of compounds, which are important for drug development.

Additionally, the structure-activity relationship of the Boswellic acid scaffold was examined in terms of its anticancer and anti-inflammatory potency. This analysis helps in understanding how the chemical structure of these compounds contributes to their biological effects.

While the review primarily focuses on the therapeutic aspects of acute inflammation and certain cancers, it also discusses the potential of boswellic acids against other disorders. This indicates that these compounds may have broader applications beyond their anti-inflammatory and anticancer properties.

It's important to note that the information provided is a summary and does not encompass all the details and findings of the review. If you are interested in specific aspects or further details, please let me know.