Visomitin (SKQ1)

Name: Visomitin (SKQ1)
Brand: Selleck Chemicals
SKU: S9729
Rating: 5 (1 reviews)

Catalog No.S9729 Purity:98.17%

Visomitin (SKQ1) is a novel mitochondrial-targeted antioxidant that holds promise in the treatment of inflammation associated with ocular surface diseases such as dry eye disease (DED) and corneal wounds. SkQ1 shows a TC50 of 317 nM on HCjE cells.

Visomitin (SKQ1) Chemical Structure

CAS No. 934826-68-3

Purity & Quality Control

Batch: Purity: 98.17%

98.17

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Related Compound Libraries	FDA-approved Drug Library Natural Product Library Bioactive Compound Library-I Express-Pick Library	Click to Expand

Biological Activity

Description	Visomitin (SKQ1) is a novel mitochondrial-targeted antioxidant that holds promise in the treatment of inflammation associated with ocular surface diseases such as dry eye disease (DED) and corneal wounds. SkQ1 shows a TC50 of 317 nM on HCjE cells.

In vitro
In vitro	Visomitin (SKQ1) is a new type of mitochondrial-targeted antioxidant, which is expected to be used to treat inflammation related to ocular surface diseases such as dry eye disease (DED) and corneal wounds. SkQ1 displays TC50 of 317 nM on HCjE cells.^[1]
Cell Research	Cell lines	Human conjunctival epithelial (HCjE) and corneal epithelial (HCLE) cells
	Concentrations	0.25 nM-250 μM
	Incubation Time	--
	Method	The SkQ1 stock solution was serially diluted in culture medium, ranging from 0.25 nM to 250,000 nM, 10 × range. As a control, the diluent (50% ethanol) was also serially diluted in culture medium, ranging from 0 to 0.75%, equivalent to the concentrations carrying over from the SkQ1 stock. Cellular morphology changes were observed and recorded and transferred to a linked computer that ran Control My Nikon v3.0 software for further analysis. Quantitative cell viability was determined by MTT assay protocols established in the laboratory.

References

[1] Yi Wei, et al. Ophthalmol Ther. 2019 Mar;8(1):63-73.

Chemical Information & Solubility

Molecular Weight	617.6	Formula	C₃₆H₄₂BrO₂P
CAS No.	934826-68-3	SDF	--
Smiles	[Br-].CC1=C(C)C(=O)C(=CC1=O)CCCCCCCCCC[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4
Storage (From the date of receipt)	2 years -20°C liquid	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	2 years -20°C liquid		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 100 mg/mL ( (161.91 mM) Warmed with 50°C water bath; Ultrasonicated; Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 50 mg/mL

Water : 3 mg/mL

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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