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Sulfopin

Synonyms: PIN1-3

Sulfopin (PIN1-3) is a highly selective covalent inhibitor of Pin1 with a Ki of 17 nM in the FP assay. Sulfopin blocks Myc-driven tumor initiation and growth in vivo.

Sulfopin Chemical Structure

Sulfopin Chemical Structure

CAS No. 2451481-08-4

Purity & Quality Control

Batch: S978201 DMSO]56 mg/mL]false]Ethanol]28 mg/mL]false]Water]3 mg/mL]false Purity: 99.91%
99.91

Sulfopin Related Products

Biological Activity

Description

Sulfopin (PIN1-3) is a highly selective covalent inhibitor of Pin1 with a Ki of 17 nM in the FP assay. Sulfopin blocks Myc-driven tumor initiation and growth in vivo.
Targets
Pin1 [1]
(in the FP assay)
17 nM(Ki)
In vitro
In vitro

Sulfopin is a highly selective covalent inhibitor of Pin1 (peptidyl-prolyl isomerase) due to target engagement and phenocopies Pin1 genetic knockout, with a Ki of 17 nM in Fluorescence polarization (FP) test.<sup><a class="sref" href="#s_ref">[1]</a></sup>
Cell Research Cell lines PATU-8988T cells
Concentrations 0.001-100 μM
Incubation Time 14 h
Method

Fluorescence polarization assay
In Vivo
In vivo

Sulfopin induces downregulation of c-Myc target genes, and reduces tumor progression and confers survival benefit in vivo.<sup><a class="sref" href="#s_ref">[1]</a></sup>
Animal Research Animal Models Mouse
Dosages 10, 20 mg/kg by o.g. over 2 days; 10, 20 or 40 mg/kg by i.p. for 2 weeks
Administration o.g., i.p.

Chemical Information & Solubility

Molecular Weight 281.80 Formula

C11H20ClNO3S
CAS No. 2451481-08-4 SDF --
Smiles CC(C)(C)CN(C1CC[S](=O)(=O)C1)C(=O)CCl
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 56 mg/mL ( (198.72 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 28 mg/mL

Water : 3 mg/mL


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In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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