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N6022

N6022 is a selective, and reversible inhibitor of S-nitrosoglutathione reductase (GSNOR) with IC50 of 8 nM and Ki of 2.5 nM. Phase 1/2.

N6022 Chemical Structure

N6022 Chemical Structure

CAS No. 1208315-24-5

Purity & Quality Control

Batch: S758901 DMSO]82 mg/mL]false]Ethanol]5 mg/mL]false]Water]Insoluble]false Purity: 99.93%
99.93

N6022 Related Products

Biological Activity

Description N6022 is a selective, and reversible inhibitor of S-nitrosoglutathione reductase (GSNOR) with IC50 of 8 nM and Ki of 2.5 nM. Phase 1/2.
Targets
S-nitrosoglutathione reductase (GSNOR) [1]
(Cell-free assay)		 S-nitrosoglutathione reductase (GSNOR) [1]
(Cell-free assay)
2.5 nM(Ki) 8 nM
In vitro
In vitro N6022 shows limited off-target activity and low cytotoxicity toward A549 epithelial lung cells. [2]
In Vivo
In vivo N6022 (30 mg/kg iv or po) reduces bronchoconstriction and pulmonary inflammation in a mouse model of asthma. [2]
Animal Research Animal Models Mouse model of asthm.
Dosages 0.0005 to 30 mg/kg
Administration i.v. or p.o.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01316315 Completed
Asthma
Nivalis Therapeutics Inc.
 March 2011 Phase 1|Phase 2
NCT01147406 Completed
Healthy
Nivalis Therapeutics Inc.
 August 2010 Phase 1

Chemical Information & Solubility

Molecular Weight 414.46 Formula

C24H22N4O3
CAS No. 1208315-24-5 SDF Download N6022 SDF
Smiles CC1=C(C=CC(=C1)C(=O)N)N2C(=CC=C2C3=CC=C(C=C3)N4C=CN=C4)CCC(=O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 82 mg/mL ( (197.84 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 5 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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