Home Others Other chemical Palmitic acid For research use only.

Palmitic acid

Synonyms: hexadecanoic acid, Cetylic acid

Palmitic acid (Hexadecanoic acid, Cetylic acid) is the most common saturated fatty acid found in animals, plants and microorganisms with anti-tumor activity.

Palmitic acid Chemical Structure

Palmitic acid Chemical Structure

CAS No. 57-10-3

Purity & Quality Control

Palmitic acid Related Products

Biological Activity

Description Palmitic acid (Hexadecanoic acid, Cetylic acid) is the most common saturated fatty acid found in animals, plants and microorganisms with anti-tumor activity.
In vitro
In vitro Palmitic acid (PA) binds TLR4 via the adaptor protein MD2 and that the TLR4 signal induced by PA stimulates dendritic cells activation and maturation accompanied by a robust IL-1β response. Palmitic acid is a TLR4/MD-2 ligand. It exerts pro-inflammatory activity through TLR4[1].
Cell Research Cell lines The insulinoma cell line INS-1
Concentrations 250 μmol/L
Incubation Time 24 or 48 h
Method The INS-1 cells are seeded onto 96-well plates at 4,000 cells/well with 10% BSA and incubated with T0901317 (10 μmol/L), palmitic acid (250 μmol/L), a combination of T0901317 and palmitic acid or PBS (mock control) for 24 or 48 h. After the treatment incubation, 20 μl of MTT solution (5 mg/mL MTT in PBS, pH 7.4) are added to each well, followed by incubation at 37°C for 4 h. The supernatants are removed from the wells and DMSO (15 μl/well) is added to dissolve the crystals. The optical density at a wavelength of 490 nm is measured using a microplate reader.
In Vivo
In vivo In a dose-dependent fashion, palmitic acid rapidly reduces mouse locomotor activity by a mechanism that did not rely on TLR4, MyD88, IL-1, IL-6 or TNFα but is dependent on fatty acid chain length. Palmitic acid induces anxiety-like behavior in mice while increasing amygdala-based serotonin metabolism[2].
Animal Research Animal Models C57BL/6J mice
Dosages 0.3, 3, and 30 μmol/mouse
Administration i.p.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05556967 Completed
Adherence Patient
University of Mississippi Medical Center|University of Mississippi National Center for Natural Products Research|National Center for Complementary and Integrative Health (NCCIH)
 August 9 2023 Not Applicable
NCT04541095 Recruiting
Weight Gain
Ospedali Riuniti Ancona|Istituto di Ricerca Pediatrica Città della Speranza|Bunge Loders Croklaan
 January 16 2023 Not Applicable
NCT03665922 Active not recruiting
Prostate Cancer
University of Pittsburgh|National Cancer Institute (NCI)
 May 1 2019 Not Applicable
NCT05791370 Completed
Diet|Healthy
Malaysia Palm Oil Board|Universiti Putra Malaysia
 January 1 2019 Not Applicable
NCT04832217 Completed
Body Weight Changes|Habits Diet|Habit Food|Life Change Events
Universidad de Zaragoza
 January 20 2019 Not Applicable

Chemical Information & Solubility

Molecular Weight 256.42 Formula

C16H32O2
CAS No. 57-10-3 SDF Download Palmitic acid SDF
Smiles CCCCCCCCCCCCCCCC(=O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 51 mg/mL ( (198.89 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 51 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.

Frequently Asked Questions

Question 1:
What should I do if S3794 cannot be dissolved or precipitated?

Answer:
Due to the specific properties of palmitic acid, emulsification may be required for dissolution. If you need technical guidance, please call our technical support.

Tags: buy Palmitic acid | Palmitic acid supplier | purchase Palmitic acid | Palmitic acid cost | Palmitic acid manufacturer | order Palmitic acid | Palmitic acid distributor