Sesamin

Name: Sesamin
Brand: Selleck Chemicals
SKU: S2392
Rating: 5 (5 reviews)

Synonyms: Fagarol, Fsesamin

Catalog No.S2392 Purity:99.86%

Sesamin (Fagarol, Fsesamin), a lignan isolated from the bark of Fagara plants and from sesame oil, exhibits various health benefits.

Sesamin Chemical Structure

CAS No. 607-80-7

Purity & Quality Control

Batch: Purity: 99.86%

99.86

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Biological Activity

Description	Sesamin (Fagarol, Fsesamin), a lignan isolated from the bark of Fagara plants and from sesame oil, exhibits various health benefits.

In vitro
In vitro	Sesamin (Fagarol) is a lignan isolated from the bark of Fagara plants and from sesame oil. It has been used as a dietary fat-reduction supplement. Sesamin truly increases fat metabolism. Sesamin specifically inhibits delta 5 desaturase at low concentrations in polyunsaturated fatty acid biosynthesis in both microorganisms and animals, but does not inhibit delta 6, delta 9 and delta 12 desaturases. ^[1] Dietary sesamin greatly increases the hepatic activity of fatty acid oxidation enzymes, including carnitine palmitoyltransferase, acyl-CoA dehydrogenase, acyl-CoA oxidase, 3-hydroxyacyl-CoA dehydrogenase, enoyl-CoA hydratase, and 3-ketoacyl-CoA thiolase. Dietary sesamin also increases the activity of 2,4-dienoyl-CoA reductase and delta3,delta2-enoyl-CoA isomerase, enzymes involved in the auxiliary pathway for beta-oxidation of unsaturated fatty acids dose-dependently. ^[2] Sesamin is also a novel inhibitor of pregnane X receptor (PXR) and may be useful for modulating CYP3A4 and drug efficacies. ^[3]

In Vivo
In vivo	LD50: Mice 3800mg/kg (i.g.); Rats 6150mg/kg (i.g.) ^[4]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT05678439	Recruiting	Sleeping Disorders	Taipei Medical University	November 18 2022	Not Applicable

References

[4] Dubey NK, et al. Plant Pathology in the 21st Century, 2009, 1, 181-198.

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Chemical Information & Solubility

Molecular Weight	354.35	Formula	C₂₀H₁₈O₆
CAS No.	607-80-7	SDF	Download Sesamin SDF
Smiles	C1C2C(COC2C3=CC4=C(C=C3)OCO4)C(O1)C5=CC6=C(C=C5)OCO6
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 71 mg/mL ( (200.36 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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