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Lycopene

Synonyms: ψ,ψ-Carotene

Lycopene (ψ,ψ-Carotene) is a linear, unsaturated hydrocarbon carotenoid, the major red pigment in fruits such as tomatoes, pink grapefruit, apricots, red oranges, watermelon, rosehips, and guava. It is a natural antioxidant., Lycopene (ψ,ψ-Carotene) is a linear, unsaturated hydrocarbon carotenoid, the major red pigment in fruits such as tomatoes, pink grapefruit, apricots, red oranges, watermelon, rosehips, and guava. It is a natural antioxidant.

Lycopene Chemical Structure

Lycopene Chemical Structure

CAS No. 502-65-8

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Lycopene Related Products

Biological Activity

Description Lycopene (ψ,ψ-Carotene) is a linear, unsaturated hydrocarbon carotenoid, the major red pigment in fruits such as tomatoes, pink grapefruit, apricots, red oranges, watermelon, rosehips, and guava. It is a natural antioxidant., Lycopene (ψ,ψ-Carotene) is a linear, unsaturated hydrocarbon carotenoid, the major red pigment in fruits such as tomatoes, pink grapefruit, apricots, red oranges, watermelon, rosehips, and guava. It is a natural antioxidant.
In vitro
In vitro Lycopene is found in nature in the all-trans form; however, thermal processing, as well as intestinal digestion, of raw tomato products facilitates its cis-isomerization[3]. Lycopene is recognized to be the most efficient singlet oxygen quencher among biological carotenoids. Antioxidant functions are associated with lowering DNA damage, malignant transformation, and reducing biological oxidative damage of proteins, lipids, and other cell components in vitro. Lycopene has also been found to increase gap-junctional communication between cells and to induce the synthesis of connexin-43[1]. It negatively affects cancer cells or development of cancer by modulating cell cycle progression and cell proliferation and has an inhibitory effect on DNA synthesis, initiating up-regulation of gap-junction proteins and a reduction of local androgen signaling, impact IGIF-1 signaling, antioxidant activity and induction of apoptotic cell death[2].
Cell Research Cell lines HT-29, T84 and MCF-7 cells
Concentrations 1-5 μM
Incubation Time 48 and 96 h
Method

Human cell lines are treated with lycopene (1-5 μM) for 48 and 96 h. Cell viability is monitored using the method of MTT. The cell cycle is analyzed by flow cytometry, and apoptotic cells are identified by terminal deoxynucleotidyl transferase-mediated dUTP nick labeling (TUNEL) and by DAPI.
In Vivo
In vivo Lycopene has been reported to increase the survival rate of mice exposed to X-ray radiation. Lycopene has been reported to increase the survival rate of mice exposed to X-ray radiation. It is found that the consumption of lycopene in fruits and vegetables may reduce the likelihood of developing heart disease. Lycopene prevents oxidation of low-density lipoprotein (LDL) cholesterol and reduces the risk of developing atherosclerosis and coronary heart disease. Lycopene is as effective as β-carotene in inhibiting the growth of the glioma cells in the model of glioma cells transplanted in rats[1]. Lycopene acts as an antioxidant agent both through a decrease in intracellular reactive species production in vitro and in vivo through the neutralization of reactive species, the restoration of the GSH/GSSG ratio, decrease in oxidatively generated damage and decrease in proinflammatory cytokines through decreased cell influx as well as direct suppression of cytokine production[3].
Animal Research Animal Models Male C57BL/6 mice
Dosages 25 or 50 mg/kg/day
Administration by orogastric gavage
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04446624 Completed
Breast Cancer|Depression Anxiety|Oxidative Stress
Università degli Studi del Piemonte Orientale Amedeo Avogadro
 February 1 2018 Not Applicable
NCT03608254 Completed
Vascular Health of Postmenopausal Women
University of Alabama Tuscaloosa
 November 5 2015 --

Chemical Information & Solubility

Molecular Weight 536.87 Formula

C40H56
CAS No. 502-65-8 SDF --
Smiles CC(=CCCC(=CC=CC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC=C(C)CCC=C(C)C)C)C)C)C
Storage (From the date of receipt) 3 years -20°C(in the dark) powder

In vitro
Batch:

0.1M NaOH : 5 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble


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