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GO-203

GO-203 is a D-amino acid cell-penetrating peptide inhibitor of MUC1-C dimerization and thereby its oncogenic function.

GO-203 Chemical Structure

GO-203 Chemical Structure

CAS No. 1222186-26-6

Purity & Quality Control

Batch: S867401 Water]100 mg/mL]false]]]false]]]false Purity: 99.77%
99.77

GO-203 Related Products

Biological Activity

Description GO-203 is a D-amino acid cell-penetrating peptide inhibitor of MUC1-C dimerization and thereby its oncogenic function.
Targets
MUC-1C [1]
In vitro
In vitro GO-203 inhibits MUC1-C homodimerization which blocks its oncogenic function. Treatment of MUC1-overexpressing SKCO-1 and Colo-205 colon cancer cells with GO-203 is associated with downregulation of the TP53-inducible glycolysis and apoptosis regulator (TIGAR) protein. GO-203 regulates AKT-S6K1-elF4A signaling in colorectal cancer cells. Targeting MUC1-C with GO-203 inhibits p-AKT in colorectal cancer cells. GO-203 treatment also results in increases in reactive oxygen species (ROS) and loss of mitochondrial transmembrane potential[1].
Cell Research Cell lines Human SW480 and LOVO colorectal cancer cells
Concentrations 5 μM
Incubation Time 48 h
Method

To assess cell viability, 20,000–30,000 cells are plated and cultured for 48 h. GO-203 and CP-2 are added at 5 μM every day for six days. Cell viability is measured by trypan blue exclusion.
In Vivo
In vivo GO-203 is effective in inhibiting growth and survival of MUC1-positive colorectal cancer cells in mouse xenograft models. It is also effective in xenografts models of breast, prostate, lung and certain hematologic malignancy[1].
Animal Research Animal Models BALB/c nu/nu male/female mice with xenograft tumor
Dosages 18 mg/kg
Administration i.p.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02204085 Active not recruiting
Acute Myeloid Leukemia in Relapse|Recurrent Adult Acute Myeloid Leukemia
Beth Israel Deaconess Medical Center|Dana-Farber Cancer Institute
 September 2014 Phase 1|Phase 2

Chemical Information & Solubility

Molecular Weight 2426.77 Formula

C87H170N52O19S2.C2HF3O2
CAS No. 1222186-26-6 SDF Download GO-203 SDF
Smiles C(CCN)CC(C(=O)NC(CC(=O)N)C(=O)O)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CS)NC(=O)C(CCC(=O)N)NC(=O)C(CS)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)N.C(=O)(C(F)(F)F)O
Storage (From the date of receipt)

In vitro
Batch:

Water : 100 mg/mL


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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