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Curcumin analog C1

Synonyms: Curcumin analog Compound C1, TFEB activator 1

Curcumin analog C1 (Curcumin analog Compound C1) is a potent transcription factor EB (TFEB) activator with promise for the prevention or treatment of Alzheimer's disease.

Curcumin analog C1 Chemical Structure

Curcumin analog C1 Chemical Structure

CAS No. 39777-61-2

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Curcumin analog C1 Related Products

Biological Activity

Description Curcumin analog C1 (Curcumin analog Compound C1) is a potent transcription factor EB (TFEB) activator with promise for the prevention or treatment of Alzheimer's disease.
Targets
TFEB [1]
In vitro
In vitro

Curcumin analog C1 specifically binds to TFEB at the N terminus and promotes TFEB nuclear translocation without inhibiting MTOR activity. By activating TFEB, Curcumin analog C1 enhances autophagy and lysosome biogenesis in N2a cells. Curcumin analog C1 (0.2-1 μM) dose-dependently increases the levels of LC3-II and SQSTM1/p62 in N2a cells.[2]
Cell Research Cell lines N2a cells, HeLa cells
Concentrations 0.2 μM-1 μM
Incubation Time 12 h
Method

N2a cells are treated with curcumin (Cur, 10 μM) and Curcumin analog C1 (1 μM) for 12 h. Cells are fixed and stained with TFEB antibody and DAPI for showing the nuclear translocation of endogenous TFEB. N2a cells are incubated with Curcumin analog C1 (1 μM) for 12 h. The protein levels of LC3B-II and SQSTM1/p62 are determined by western blotting. N2a and HeLa cells are treated with Curcumin analog C1 (0.5, 1 μM) or sucrose (100 mM) for 12 h. The protein levels of the autophagy marker (LC3B-II), TFEB, and lysosome markers (LAMP1, CTSD) are determined by western blotting.
In Vivo
In vivo

The LD50 value of Curcumin analog C1 is 175 mg/kg in the acute toxicity assay. Short-term oral administration of Curcumin analog C1 (low dosage 10 mg/kg and high dosage 25 mg/kg; for 24 h) dose-dependently increases the expression of LC3B-II and TFEB in the liver, frontal cortex and striatum of the brain. Chronic administration of Curcumin analog C1 (10 mg/kg; daily; for 21 days) activates TFEB and enhances autophagy in rat brains. [2]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06371417 Not yet recruiting
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X-linked Adrenoleukodystrophy
Minoryx Therapeutics S.L.
 January 2 2024 --
NCT06317467 Recruiting
Pre-Eclampsia
IRCCS Burlo Garofolo
 September 13 2023 --
NCT05578417 Recruiting
Hereditary Angioedema (HAE)|Angioedema
Takeda
 June 15 2023 --
NCT05833620 Not yet recruiting
Hereditary Angioedema With C1 Esterase Inhibitor Deficiency
Hospital Universitari Vall d''Hebron Research Institute|Hospital Universitario La Paz
 May 2023 --

Chemical Information & Solubility

Molecular Weight 294.34 Formula

C19H18O3
CAS No. 39777-61-2 SDF --
Smiles COC1=CC=CC=C1C=CC(=O)C=CC2=CC=CC=C2OC
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 30 mg/mL ( (101.92 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 2 mg/mL

Water : Insoluble


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In vivo
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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