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Methyl-β-cyclodextrin (MβCD)

Synonyms: Methyl-beta-cyclodextrin, M-β-CyD, Methyl-β-CD

Methyl-β-cyclodextrin (MβCD) is a cholesterol-removing agent mainly used for lipid raft disruption. Methyl-β-cyclodextrin induces caspase-dependent apoptosis in PEL cells and inhibits the growth and invasion of PEL cells without apparent adverse effects, suggesting the potential effective antitumor activities.

Methyl-β-cyclodextrin (MβCD) Chemical Structure

Methyl-β-cyclodextrin (MβCD) Chemical Structure

CAS No. 128446-36-6

Purity & Quality Control

Methyl-β-cyclodextrin (MβCD) Related Products

Biological Activity

Description Methyl-β-cyclodextrin (MβCD) is a cholesterol-removing agent mainly used for lipid raft disruption. Methyl-β-cyclodextrin induces caspase-dependent apoptosis in PEL cells and inhibits the growth and invasion of PEL cells without apparent adverse effects, suggesting the potential effective antitumor activities.
Targets
cholesterol [1] lipid raft [1]
In vitro
In vitro

Methyl-β-cyclodextrin Inhibits SDF-1α-induced platelet aggregation and Akt phosphorylation by raft disruption.[2]
Cell Research Cell lines Platelets
Concentrations 2%
Incubation Time 15 min
Method

Freshly isolated human platelets are incubated with SDF-1α and centrifuged for 1 min at 3000 rpm. The resulting pellet is resuspended and boiled in Laemmli sample buffer containing phosphatase inhibitor cocktails 2 and 3. Phosphorylations of Akt (Ser473) is detected by western blotting. Platelet aggregation is measured as the optical density of PRP during aggregation using a platelet aggregometer, with the platelet-poor plasma 100% standard for change in optical density.
In Vivo
In vivo

In a Primary effusion lymphoma (PEL) xenograft mouse model, Methyl-β-cyclodextrin significantly inhibits the growth and invasion of PEL cells without apparent adverse effects. Methyl-β-cyclodextrin-treated mice appears to be healthy, whereas non-treated mice has a distended abdominal region. The body weights of control are significantly higher than those of Methyl-β-cyclodextrin treated mice. Methyl-β-cyclodextrin-treated mice has a significantly lower volume of ascites than that of non-treated mice.[1]

Chemical Information & Solubility

Molecular Weight Formula
CAS No. 128446-36-6 SDF --
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

Water : 100 mg/mL


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In vivo
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