SR8278

Name: SR8278
Brand: Selleck Chemicals
SKU: S0502
Rating: 5 (1 reviews)

Catalog No.S0502 Purity:99.76%

SR8278 is a competitive antagonist of nuclear heme receptor REV-ERB with an EC50 of 0.47 μM for REV-ERBα.

SR8278 Chemical Structure

CAS No. 1254944-66-5

Purity & Quality Control

Batch: S050201 DMSO]72 mg/mL]false]Ethanol]72 mg/mL]false]Water]Insoluble]false Purity: 99.76%

99.76

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Biological Activity

Description

SR8278 is a competitive antagonist of nuclear heme receptor REV-ERB with an EC50 of 0.47 μM for REV-ERBα.

Targets

REV-ERBα ^[1]

0.47 μM(EC50)

References

[1] Douglas Kojetin, et al. ACS Chem Biol . 2011 Feb 18;6(2):131-4.

Chemical Information & Solubility

Molecular Weight	361.48	Formula	C₁₈H₁₉NO₃S₂
CAS No.	1254944-66-5	SDF	--
Smiles	CCOC(=O)C1CC2=CC=CC=C2CN1C(=O)C3=CC=C(S3)SC
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 72 mg/mL ( (199.18 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 72 mg/mL

Water : Insoluble

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In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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