L-Tryptophan

Name: L-Tryptophan
Brand: Selleck Chemicals
SKU: S3987
Rating: 5 (1 reviews)

Catalog No.S3987 Purity:99.28%

L-tryprophan is an essential amino acid that acts like a natural mood regulator that is necessary for normal growth in infants and for nitrogen balance in adults.

L-Tryptophan Chemical Structure

CAS No. 73-22-3

Purity & Quality Control

Batch: S398701 DMSO]11 mg/mL]false]]]false]]]false Purity: 99.28%

99.28

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Biological Activity

Description	L-tryprophan is an essential amino acid that acts like a natural mood regulator that is necessary for normal growth in infants and for nitrogen balance in adults.

In Vivo
In vivo	L-Tryptophan suppresses both serum glucose and insulin levels after oral glucose administration and inhibits glucose absorption from the intestine. It increases glucose-associated energy expenditure in rats in vivo. L-Tryptophan suppresses the rapid rise in blood glucose after a glucose-rich meal and lessens the burden of insulin secretion from β-cells. Oral administration of L-tryptophan is more effective than intraperitoneal injection^[1].
Animal Research	Animal Models	Four-week-old male normal Sprague-Dawley rats
	Dosages	62.5 mg/kg
	Administration	Oral administration

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT06283706	Not yet recruiting	Healthy Aging	The Hospital for Sick Children\|Canadian Institutes of Health Research (CIHR)	June 1 2024	Not Applicable
NCT06365801	Not yet recruiting	Irritable Bowel Syndrome	The Third Affiliated hospital of Zhejiang Chinese Medical University	April 2024	--
NCT06228352	Not yet recruiting	Ulcerative Colitis	Assistance Publique - Hôpitaux de Paris	March 2024	--
NCT06021535	Not yet recruiting	Aortic Stenosis\|Gastrointestinal Microbiome\|Metabolomics	Insel Gruppe AG University Hospital Bern	January 1 2024	--

References

[1] Tomoko Inubushi, et al. J Nutr Sci Vitaminol. 2012, 58:415-422.

Chemical Information & Solubility

Molecular Weight	204.23	Formula	C₁₁H₁₂N₂O₂
CAS No.	73-22-3	SDF	--
Smiles	C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)N
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 11 mg/mL ( (53.86 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Molecular Weight Calculator

In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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